儿童肥胖与糖耐量的关系研究

Relationship between Obesity and Glucose Tolerance in Children

目的:探讨儿童肥胖与糖耐量的关系。方法:将44例单纯性肥胖儿童和同期来某院接受健康体检的44例儿童分别设为研究组和对照组,对比两组儿童的糖耐量异常率。为研究组制定肥胖干预措施进行肥胖干预,对比研究组儿童进行肥胖干预前、干预后1个月、干预后2个月糖负荷后1h、2h的血糖浓度。结果:研究组糖耐量异常率为29.54%,高于对照组的2.27%(P<0.05);肥胖干预后2个月,研究组糖负荷后1h、2h的血糖均低于干预后1个月和干预前(P<0.05);肥胖干预后1个月,糖负荷后1h、2h的血糖浓度与干预前比较存在的差异也具有统计学意义(P<0.05)。结论:肥胖是诱导儿童发生糖耐量异常的重要危险因素,及时采取措施进行干预,有利于降低儿童2型糖尿病的发生率。

Objective:To explore the relationship between obesity and glucose tolerance in children.Methods:44 cases of children with simple obesity and 44 cases of healthy children at the same time were divided into study group and control group.The abnormal rate of glucose tolerance between the two groups were compared.The obesity intervention measures were developed for the study group,and the blood glucose concentration of 1 h,2 hafter sugar loading in the study group before obesity intervention,after 1 months after intervention,and after 2 months of intervention were compared.Results:The rate of abnormal glucose tolerance in study group was 29.54%,which was higher than that in the control group(2.27%)(P<0.05).2 months after obesity intervention,the blood glucose of 1 hand 2 hafter glucose loading in study group was lower than that in 1 month after intervention and before intervention.(P<0.05).There was significant difference in the blood glucose of 1 hand 2 hafter glucose loading between 1 months after the intervention of obesity and before the intervention(P<0.05).Conclusion:Obesity is an important risk factor for the induction of glucose tolerance in children,and timely intervention is beneficial to reduce the incidence of type 2 diabetes in children.