雷替曲塞、奥沙利铂联合手术治疗局部晚期结直肠癌的临床疗效观察

Clinical Observation of Raltitrexed and Oxaliplatin Combined with Surgery in the Treatment of Locally Advanced Colorectal Cancer

目的:探究雷替曲塞、奥沙利铂与手术联合治疗局部晚期结直肠癌的效果。方法:在某院收治的局部晚期结直肠癌患者中选出100例为研究对象随机分组,对照组患者给予常规结直肠癌根治术,实验组患者在手术的基础上给予雷替曲塞和奥沙利铂术中动脉灌注化疗,对比两组患者的术后并发症发生率等。结果:实验组患者的恶心呕吐、腹泻、血小板减少发生率低于对照组,且术后2年生存率高于对照组,术后2年局部复发率、肝脏转移率低于对照组,P<0.05;两组患者的贫血、吻合口瘘、切口感染、肠梗阻发生率差异不大,且1年生存率差异不大,P>0.05。结论:对行手术治疗的局部晚期结直肠癌患者术中应用雷替曲塞联合奥沙利铂动脉灌注化疗有助于提高治疗效果,预防肿瘤复发和转移,值得推广。

Objective:To investigate the effect of raltitrexed and oxaliplatin in the treatment of locally advanced colorectal cancer.Methods:100 patients locally advanced colorectal cancer treated in a hospital were randomly selected and divided into control group and experimental group.The control group was given conventional radical resection of colorectal cancer,and the experimental group was given intraoperative arterial infusion chemotherapy with retitrexide and oxaliplatin on the basis of operation,then the incidence of postoperative complications in the two groups was compared.Results:The incidence of nausea,vomiting,diarrhea and thrombocytopenia in experimental group was lower than that in control group,the postoperative 2 year survival rate was higher than that in the control group,and the local recurrence rate and liver metastasis rate at 2 years after operation were lower than those in the control group(P<0.05);There was no significant difference in the incidence of anemia,anastomotic fistula,incision infection and intestinal obstruction between the two groups,and the difference in 1-year survival rate was not significant(P>0.05).Conclusion:The intraoperative application of raltitrexed combined with oxaliplatin arterial infusion chemotherapy in patients with locally advanced colorectal cancer undergoing surgical treatment can improve the therapeutic effect,prevent tumor recurrence and metastasis,and is worthy of promotion.