来氟米特单独及联合甲氨蝶呤对类风湿关节炎患者体征改善及血清CRP、ESR水平变化的影响

Effects of Leflunomide Alone and Combined with Methotrexate on the Improvement of Physical Signs and the Changes of Serum CRPU and ESR Levels in Patients with Rheumatoid Arthritis

目的:探究在类风湿关节炎治疗的过程中,使用来氟米特单独治疗及联合甲氨蝶呤治疗的效果。方法:针对40例类风湿关节炎患者采用来氟米特单独治疗,并归为对照组,针对另外40例患者在对照组基础上联合使用甲氨蝶呤治疗,并归为观察组,两组患者均为某院2014年9月~2016年12月间收治。结果:两组患者治疗后观察组患者的ESR和CRP均明显较优;两组患者治疗后,观察组患者的治疗有效率95.0%明显较高(对照组为70.0%),组间比较P<0.05,说明两组数据差异明显;两组患者的不良反应发生率均为2.5%,组间比较差异不具有统计学意义。结论:来氟米特单独及联合甲氨蝶呤对类风湿关节炎患者体征改善及血清CRP、ESR水平变化的影响均具有一定作用,其中来氟米特联合甲氨蝶呤治疗能够使得患者体征得到明显改善,其能够提高患者治疗的效果,对血清CRP、ESR水平变化的影响也更加积极,因此值得临床借鉴。

Objective:To investigate the effect of leflunomide alone and combined with methotrexate on the improvement of physical signs and the changes of serum CRPU and ESR levels in patients with rheumatoid arthritis.Methods:40 cases of patients with rheumatoid arthritis were given leflunomide treatment alone and classified as control group,and the other 40 patients was given methotrexate treatment based on the control group and classified as observation group.All patients were treated in a hospital from September 2014 to December 2016.Results:The ESR and CRP of the observation group after treatment were better than those of the control group,effective rate of treatment in the observation group was significantly higher than that in the control group after treatment(95.0% vs 70.0%)(P<0.05).The incidence of adverse reactions in the two groups was 2.5%,and the difference between the groups was not statistically significant.Conclusion:Leflunomide alone and in combination with methotrexate have a certain effect on the improvement of physical signs and the changes of serum CRP and ESR levels in patients with rheumatoid arthritis.Leflunomide combined with methotrexate can significantly improve the patient's physical signs,which can improve the efficacy of the treatment,and the effect on the serum CRPU and ESR level is more positive.Therefore,it is worthy of clinical reference.