甲磺酸阿帕替尼片治疗胃肠恶性肿瘤合并腹水的临床疗效研究

Efficacy of apatinib mesylate tablets in the treatment of malignant gastrointestinal tumors complicated with ascites

目的探讨甲磺酸阿帕替尼片治疗胃肠恶性肿瘤合并腹水的临床疗效。方法选取2015年11月至2017年5月间上海市宝山区中西医结合医院收治的60例胃肠恶性肿瘤合并腹水患者,根据治疗方式不同分为观察组与对照组,每组30例。观察组患者在对照组治疗基础上采用甲磺酸阿帕替尼片治疗,对照组患者采用一般常规治疗。比较两组患者的客观有效率、生活质量改善情况与不良反应发生情况。结果观察组患者客观有效率为78.6%,明显高于对照组的43.3%,差异有统计学意义(P<0.05)。观察组患者生活质量改善率为71.4%,明显高于对照组的40.0%,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论甲磺酸阿帕替尼片可明显提高胃肠恶性肿瘤合并腹水患者客观有效率,改善生活质量,利于减轻患者生理与心理痛苦,提高治疗依从性,延长生存时间。

Objective To investigate the clinical efficacy of apatinib mesylate tablets in the treatment of malignant gastrointestinal tumors complicated with ascites. Methods A total of 60 patients with malignant gastrointestinal tumors combined complicated ascites treated at Shanghai Baoshan District Integrated Hospital of Traditional and Western Medicine from November 2015 to May 2017 were selected and they were divided into an observation group and a control group according to the therapies with 30 patients in each group. The observation group was given apatinib mesylate tablets and the control group was treated with conventional medicine. The objective response rate,improvement in quality of life and adverse reactions were compared between the two groups. Results The objective response rate was 78. 6% in the observation group which was significantly higher than 43. 3% of the control group（ P〈0. 05）. The improvement in quality of life was 71. 4% in the observation group which was significantly higher than 40. 0% of the control group（ P〈0. 05）. No significant difference was noted in the incidence of adverse reactions between the two groups（ P〈0. 05）. Conclusion Apatinib mesylate tablets can significantly increase the objective response rate,improve quality of life,reduce physical and psychological pain and enhance treatment compliance which helps to prolong survival period.