铜催化的芳烃胺化的研究

Study on Aromatic Amination Catalyzed by Copper

在过渡金属铜催化作用下,芳烃与N-氯代酞酰亚胺进行C—N键偶联,实现了芳烃的C—H键的胺化。考察了反应溶剂、催化剂种类、反应时间、反应温度及芳烃结构对反应的影响,确定了较佳的反应条件:0.5mmol N-氯代酞酰亚与2mL芳烃反应,在溴化铜(10mol%)、醋酸碘苯(2mmol)作用下,反应温度为130℃,时间为8h。在此反应条件下,富电子的芳烃反应较好,缺电子的芳烃反应相对较差。

C—N coulping between arene and N-chlorophthalimide was realized by copper catalysed C—H activation,affording aminated arene.Reaction conditions including solvent,catalyst,reaction time,and diverse arenes were investigated.The optimized condition is described as follows：0.5 mmol Nchlorophthalimide,2 mL neat arene,and 2 mmol iodobenzene diacetate in the presence of 10 mol% copper acetate at 130 ℃ for 8 h.In general,the electron rich arenes have higher reactivity than electron-poor arenes.