武汉协和医院354例肝硬化患者流行病学情况及发病的时间规律性研究

Epidemiology and seasonal variation in the onset of cirrhosis:analysis of 354 cases in Wuhan union hospital

[目的]探讨武汉协和医院354例肝硬化患者流行病学情况及发病时间是否存在时间规律性,为进一步防治肝硬化提供依据。[方法]回顾性分析武汉协和医院2009年1月~2014年1月354例肝硬化患者的临床资料,分析其发病的时间规律性。[结果]本组患者男206例,占58.19%;女148例,占41.81%;发病年龄51~60岁为高发年龄段;病因以乙型病毒性肝炎最多见,占45.19%;肝硬化最常见的并发症是门静脉高压(96.61%);患者就诊的主要原因是上消化道出血(40.11%)。肝硬化的总体发病时间以3月份最多。[结论]肝硬化存在3月份发病率上升的时间规律性,乙肝肝硬化是肝硬化的主要病因之一,防治病毒性肝炎是预防肝硬化的重要手段。积极防治肝硬化并发症上消化道出血是延长患者生命最重要的环节。

[Objective]To provide basis for the prevention and treatment for cirrhosis via exploring the epidemiology and the possible existence of a seasonal variability in its onset. [Methods]354 hospitalized ca- ses of cirrhosis, from January 2009 to January 2014, were retrospectively analyzed for seasonal variation. [Results]The data include 206 male patients（58.19%）and 148 female patients（41.81%）. High incidence falls in the age range from 51 to 60 years. Viral hepatitis B is the most common cause of cirrhosis（45.19%）; The biggest complication（96.61%）is portal hypertension~ The patients were mainly hospitalized for upper gastrointestinal hemorrhage（40.11 %）. There was significant difference in overall incidence of cirrhosis on- set time,March had the highest incidence. [Conclusion]Seasonal pattern in the onset of cirrhosis, with a peak in March, is confirmed. Hepatitis B induced cirrhosis is the main cause of the incidence in Hubei, therefore prevention and treatment of viral hepatitis is an important approach for preventing cirrho- sis. Prevention and treatment of its complication, upper gastrointestinal hemorrhage, is the key that pro- longs life of patients.