中枢神经系统退行性病变研究中RNA-seq技术的应用

The application of RNA-seq in neurodegenerative diseases

RNA测序技术(RNA-seq)作为近年兴起的研究方法,已被应用于各种疾病的研究,尤其在二代测序(NGS)技术引进后,RNA-seq在中枢神经系统(CNS)研究中的应用也日益受到关注。文章就RNA-seq的发展及其在一些中枢神经系统退行性病变中的研究进行综述。主要以帕金森病、阿尔兹海默症及亨廷顿氏病为例介绍基于RNA-seq的转录组学研究在中枢神经系统疾病中的应用,同时对其在预测中枢神经系统疾病药物治疗靶点研究的前景进行展望。

As a noval approach,RNA sequencing（RNA-seq） has been used for studying many diseases in recent years,especially with the introduction of next generation sequencing（NGS）,much more and more attention has been gathered on the utilization of RNA-seq for research purpose of central nervous system（CNS）.This review focuses on applying of RNA-seq in central nervous system,taking neurodegenerative diseases for example,including Alzheimer＇s disease,Parkinson＇s disease and Huntington＇s disease,to expound the application of RNA-seq in the studying of central nervous system diseases and the prospective side of finding potential targets in drug treatment of neurodegenerative diseases.