EICU患者病情危重程度与Ghrelin及促炎因子的相关性研究

Relationship between Ghrelin,pro-inflammatory factors and the condition of critically ill patients in EICU

目的:分析急诊重症监护病房(EICU)患者病情危重程度与Ghrelin及促炎因子之间的关系。方法:随机选取我院EICU收治的85例重症患者,根据APACHEⅡ评分分为高危组和低危组。分别检测记录并比较两组患者血清辛酰基化Ghrelin、肿瘤坏死因子α(TNF-α)、白介素6(IL-6)、白细胞介素8(IL-8)、乳酸和C反应蛋白(CRP)水平、EICU住院时间、住院费用及病死率,并分析血清辛酰基化Ghrelin水平与其他各指标之间的相关性。结果:高危组患者的血浆辛酰基化Ghrelin、TNF-α、IL-6、IL-8、CRP及乳酸水平均显著高于低危组(P<0.05),且高危组住院时间、住院费用及病死率与低危组比较差异有统计学意义(P<0.05);辛酰基化Ghrelin水平与APACHEⅡ评分、IL-6、IL-8、TNF-α成正相关(P<0.05)。结论:患者辛酰基化Ghrelin水平越高,病情越危重。

Objective：To analyze the relationship between serum Ghrelin,pro-inflammatory factors and the condition of patients in emergency intensive care unit（EICU）critically ill patients.Method：Eighty-five critically ill patients in EICU were enrolled and divided into high-risk group and low-riskgroup according to the APACHEⅡscore.Serum acylated Ghrelin,pro-inflammatory factors including tumor necrosis factorα（TNF-α）,interleukin 6（IL-6）,interleukin 8（IL-8）,lactic acid and c-reactive protein（CRP）,length of stay（LOS）in EICU,hospital costs and mortality rate were compared between two groups.The correlation between serum Ghrelin levelsand other indicators were analyzed.Result：The level of acylated Ghrelin,TNF-α,IL-6,IL-8,CRP and lactic acid in the patients of high-risk group was significantly higher than that in low-risk group（P0.05）.There were also significant differences between two groups in EICU LOS,hospitalization costs and mortality rate（P0.05）.The level of acylated Ghrelin was positively correlated with APACHEⅡ score,IL-6,IL-8 and TNF-α（P0.05）.Conclusion：The higher acylated Ghrelin in critically ill patients,the higher risk in critically ill patients.