老年精神病并发退行性心瓣膜病的危险因素探讨

The risk factors of senile psychosis complicated with degenerative valvular heart disease

目的探讨老年精神病并发退行性心瓣膜病(DVCD)的危险因素。方法选取本院2015年9月~2016年12月收治的老年精神病患者共120例作为观察组,同期健康查体的老年人120例作为对照组,对比两组DCVD的检出率,将观察组按照有无发生DCVD分为DCVD组和非DCVD组,对其可能存在的危险因素进行单因素及多因素Logistic回归分析。结果观察组DCVD检出率(50.83%)明显高于对照组(21.67%),差异有统计学意义(P<0.05);老年精神病患者DCVD男性检出率(28.33%)明显高于女性(17.50%),差异有统计学意义(P<0.05),随着年龄的增长,老年精神病患者DCVD的检出率呈现增加的趋势;DCVD组高血压、高血脂的比率及总胆固醇和低密度脂蛋白水平明显高于非DCVD组,差异有统计学意义(P<0.05);多元logistic回归分析显示年龄、男性、服用精神病药物病史、高血压及高脂血症是老年患者发生DCVD的独立危险因素(P<0.05)。结论 DHVD是一种好发于老年男性,且随年龄改变的一种心脏病服精神类药物者更容易导致DHVD的发生,同时临床上应警惕高脂血症及高血压患者。

Objective To explore the risk factors of senile psychosis complicated with degenerative valvular disease(DVCD). Methods In our hospital from September 2015 to December 2016 were elderly psychiatric patients with a total of 120 cases as the observation group, the elderly healthy as control group of 120 cases, the detection rate was compared between the two groups of DCVD, the observation group according to whether the occurrence of DCVD is divided into DCVD group and non DCVD, the possible the risk factors were analyzed by univariate and multivariate logistic regression analysis. Results In the observation group, the positive rate of DCVD(50.83%) was significantly higher than the control group(21.67%), the difference was statistically significant(P<0.05); elderly psychiatric patients DCVD detection rate of male(28.33%) was significantly higher than that in female(17.50%), the difference was statistically significant(P<0.05), with the increase of age DCVD, elderly patients with mental disease incidence increased; the ratio of DCVD group of hypertension and high blood fat and total cholesterol and low density lipoprotein levels were significantly higher than those in non DCVD group, the difference was statistically significant(P<0.05); multivariate logistic regression analysis showed that age, male, taking antipsychotic drugs, medical history hypertension and hyperlipidemia are independent risk factors for elderly patients with DCVD(P< 0.05). Conclusion DHVD is a kind of heart disease that is good for elderly men and changes with age. Psychotropic drugs are more likely to cause DHVD. At the same time, we should be vigilant for hyperlipidemia and hypertension.