乌司他丁联合奥曲肽治疗重症急性胰腺炎的疗效观察

Observation on efficacy of ulinastatin combined with octreotide in the treatment of severe acute pancreatitis

目的分析乌司他丁联合奥曲肽治疗重症急性胰腺炎的疗效。方法 104例重症急性胰腺炎患者,分为对照组(50例)和观察组(54例)。两组患者采取常规治疗,在此基础上对照组患者采取奥曲肽治疗;观察组患者采取乌司他丁联合奥曲肽治疗。比较两组患者治疗效果、症状缓解时间、住院时间、全身炎症反应综合征(SIRS)持续时间、中转手术率及治疗前后血淀粉酶、C反应蛋白、中性粒细胞计数水平。结果观察组患者总有效率为90.47%,高于对照组的68.00%,差异具有统计学意义(P<0.05)。观察组患者症状缓解时间、住院时间、SIRS持续时间均短于对照组,中转手术率低于对照组,差异具有统计学意义(P<0.05)。观察组治疗后血淀粉酶、C反应蛋白、中性粒细胞计数水平均低于对照组,差异具有统计学意义(P<0.05)。结论乌司他丁联合奥曲肽可协同提高重症急性胰腺炎的疗效,促进病情转归,原因与抑制炎症反应密切相关。

Objective To analyze the efficacy of ulinastatin combined with octreotide in the treatment of severe acute pancreatitis. Methods A total of 104 patients with severe acute pancreatitis were randomly divided into control group（50 cases） and observation group（54 cases）. Both groups received conventional therapy, and the control group also received octreotide for treatment. The observation group received ulinastatin combined with octreotide for treatment. Comparison were made on treatment effect, symptom remission time, hospitalization time, duration of systemic inflammatory response syndrome（SIRS）, surgery-conversion rate, and blood amylase, C reactive protein, and neutrophils count levels before and after treatment between the two groups. Results The observation group had higher total effective rate as 90.47% than 68.00% in the control group, and the difference was statistically significant（P〈0.05）. The observation group had shorter symptom remission time, hospitalization time, duration of SIRS than the control group, and lower surgery-conversion rate than the control group. Their difference was statistically significant（P〈0.05）. After treatment, the observation group had lower blood amylase, C reactive protein, and neutrophils count levels than the control group, and the difference was statistically significant（P〈0.05）. Conclusion Combination of ulinastatin and octreotide can improve the efficacy of severe acute pancreatitis and promote the outcome of the disease, and the reason is closely related to the inhibition of inflammatory response.