胃溃疡合并幽门螺杆菌感染采用泮托拉唑治疗的临床观察

Clinical observation of pantoprazole in the treatment of gastric ulcer complicated with Helicobacter pylori infection

目的分析胃溃疡合并幽门螺杆菌(Hp)感染采用泮托拉唑治疗的临床效果。方法 106例合并Hp感染的胃溃疡患者作为研究对象,根据治疗方法不同分为观察组(55例)与对照组(51例)。对照组患者采用阿莫西林及克拉霉素联合法莫替丁治疗,观察组患者采用阿莫西林及克拉霉素联合泮托拉唑治疗。比较两组胃镜下溃疡愈合效果、治疗前后溃疡周围组织成熟度、Hp根除率、溃疡复发率、不良反应发生率。结果观察组胃镜下溃疡愈合总有效率为96.36%,明显高于对照组的84.31%,差异具有统计学意义(P<0.05)。治疗前,两组患者溃疡周围组织成熟度比较差异无统计学意义(P>0.05);治疗后,观察组患者溃疡周围组织成熟度明显优于对照组,差异具有统计学意义(P<0.05)。观察组Hp根除率、不良反应发生率分别为83.64%、12.73%,与对照组的78.43%、11.76%比较差异无统计学意义(P>0.05);观察组溃疡复发率为5.45%,明显低于对照组的19.61%,差异具有统计学意义(P<0.05)。结论泮托拉唑治疗胃溃疡合并Hp感染的效果显著,可有效提高胃溃疡愈合质量,抑制病情复发,且安全性尚可,值得临床推广采用。

Objective To analyze the clinical effect of pantoprazole in the treatment of gastric ulcer complicated with Helicobacter pylori（Hp） infection. Methods A total of 106 gastric ulcer patients with Hp infection as study subjects were divided by different treatment methods into observation group（55 cases） and control group（51 cases）. The control group received amoxicillin and clarithromycin in combination with famotidine for treatment, and the observation group received amoxicillin and clarithromycin in combination with pantoprazole for treatment. Comparison were made on healing effect of ulcers under gastroscope, tissue maturity around ulceration before and after treatment, Hp eradication rate, ulcer recurrence rate and incidence of adverse reactions between two groups. Results The observation group had obviously higher total effective rate of ulcers healing under gastroscope as 96.36% than 84.31% in the control group, and the difference was statistically significant（P〈0.05）. Before treatment, both groups had no statistically significant difference in tissue maturity around ulceration（P〉0.05）. After treatment, the observation group had obviously better tissue maturity around ulceration than the control group, and the difference was statistically significant（P〈0.05）. The observation group had Hp eradication rate and incidence of adverse reactions respectively as 83.64% and 12.73%, and there was no statistically significant difference comparing with 78.43% and 11.76% in the control group（P〉0.05）. The observation group had obviously lower ulcer recurrence rate as 5.45% than 19.61% in the control group, and the difference was statistically significant（P〈0.05）. Conclusion Pantoprazole shows remarkable effect in treating gastric ulcer complicated with Hp infection, and can effectively improve the healing quality of gastric ulcer, inhibit the recurrence of the disease. It is safe and worthy of clinical promotion and application.