甘精胰岛素联合瑞格列奈对2型糖尿病患者血糖控制及低血糖发生率的影响

Effects of insulin glargine combined with repaglinide on blood glucose control control and incidence of hypoglycemia in type 2 diabetic mellitus patients

目的研究甘精胰岛素联合瑞格列奈对2型糖尿病患者血糖控制及低血糖发生率的影响。方法 84例2型糖尿病患者,依照治疗方案不同分为观察组与对照组,各42例。对照组予以甘精胰岛素治疗,观察组在对照组基础上联合瑞格列奈治疗。观察比较两组治疗前后血糖指标[空腹血糖(FBG)、餐后2 h血糖(PBG)、糖化血红蛋白(Hb A1c)]水平、临床治疗效果及低血糖发生情况。结果治疗后,观察组患者中显效24例、有效15例、无效3例,临床治疗总有效率为92.86%(39/42);对照组患者中显效17例、有效14例、无效11例,临床治疗总有效率为73.81%(31/42);观察组患者临床治疗总有效率明显高于对照组,差异具有统计学意义(χ~2=5.486,P=0.019<0.05)。治疗前,两组患者FBG、PBG、Hb A1c水平比较差异无统计学意义(P>0.05);治疗后,两组患者FBG、PBG、Hb A1c水平均降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。观察组发生低血糖2例,低血糖发生率为4.76%(2/42);对照组发生低血糖11例,低血糖发生率为26.19%(11/42);观察组患者低血糖发生率明显低于对照组,差异具有统计学意义(χ~2=7.372,P=0.007<0.05)。结论甘精胰岛素联合瑞格列奈治疗2型糖尿病具有显著效果,可有效控制患者血糖水平,且低血糖发生率较低。

Objective To study the effect of insulin glargine combined with repaglinide on blood glucose control control and incidence of hypoglycemia in type 2 diabetic mellitus patients. Methods A total of 84 type 2 diabetic mellitus patients were divided by different treatment regimens into observation group and control group, with 42 cases in each group. The control group was treated with insulin glargine, and the observation group was treated with repaglinide on the basis of the control group. Observation and comparison were made on blood glucose index （fasting blood glucose （FBG）, 2 h postprandial blood glucose （PBG）, glycosylated hemoglobin （HbAlc） ] level before and after treatment, clinical treatment effect and occurrence ofhypoglycemia between the two groups. Results After treatment, the observation group had 24 excellent cases, 15 effective cases and 3 ineffective cases, with total effective rate of clinical treatment as 92.86% （39/42）, while the control group had 17 excellent cases, 14 effective cases and 11 ineffective cases, with total effective rate of clinical treatment as 73.81% （31/42）. The observation group had obviously higher total effective rate of clinical treatment than the control group, and the difference was statistically significant （X^2=5.486, P=0.019〈0.05）. Before treatment, both groups had no statistically significant difference in FBG, PBG and HbAlc level （P〉0.05）. After treatment, both groups had lower FBG, PBG and HbAlc level, and the observation group was lower than the control group. Their difference was statistically significant （P〈0.05）. The observation group had 2 cases of hypoglycemia, with incidence of hypoglycemia as 4.76% （2/42）, while the observation group had 11 cases of hypoglycemia, with incidence of hypoglycemia as 26.19% （11/42）. The observation group had obviously lower incidence of hypoglycemia than the control group, and the difference was statistically significant （X2=7.372, P=0.007〈0.05）. Conclusion Combination of insulin glargine and repaglinide shows remarkable effect in treating type 2 diabetic mellitus, and can effectively control the blood glucose level with low incidence of hypoglycemia.