脑钠肽、超敏C-反应蛋白、超敏肌钙蛋白Ⅰ水平对急性冠脉综合征患者病变严重程度及预后评估的临床意义

Clinical significance of BNP,hs-CRP and TnIU1tr levels in evaluating the severity and prognosis of patients with acute coronary syndrome

目的探讨脑钠肽(BNP)、超敏C-反应蛋白(hs-CRP)、超敏肌钙蛋白I(TnIU1tr)对急性冠脉综合征患者病变严重程度及预后的影响。方法选取120例急性冠脉综合征患者作为研究对象,其中不稳定型心绞痛(UA)42例、ST段抬高心肌梗死(STEMI)47例、无ST段抬高心肌梗死(NSTEMI)31例,另选取同期于本院体检的40例健康志愿者为对照组,检测各组对象的BNP、hs-CRP、TnIU1tr水平,并根据病变支数及是否发生心血管事件分组比较BNP、hs-CRP、TnIU1tr水平。结果各组患者的BNP、hs-CRP及TnIU1tr水平高于对照组,差异均有统计学意义(P<0.05);UA组、NSTEMI组、STEMI组的BNP、hs-CRP及TnIU1tr水平依次升高;单支病变组、双支病变组、3支病变组的BNP、hs-CRP及TnIU1tr水平依次升高;发生心血管事件组的BNP、hs-CRP及TnIU1tr水平高于未发生心血管事件组,上述差异均有统计学意义(P<0.05)。结论 BNP、hs-CRP及TnIU1tr水平与急性冠脉综合征病变严重程度密切相关,并具有评估预后的价值。

Objective To investigate the effects of brain natriuretic peptide（ BNP）,hypersensitive C reactive protein（ hs-CRP） and high sensitive troponin I（ TnIU1tr） on the severity and prognosis of patients with acute coronary syndrome（ ACS）.Methods 120 patients with acute coronary syndrome were enrolled in this study,including 42 with cases unstable angina pectoris（ UA）,47 cases with ST segment elevation myocardial infarction（ STEMI）,and 31 cases with no ST segment elevation myocardial infarction（ NSTEMI）,another 40 healthy volunteers who were examined in our hospital during the same period were selected as the control group. The levels of BNP,hs-CRP and TnIU1tr in each group were detected,and the levels of BNP,hs-CRP and TnIU1tr were compared according to the number of lesions and the occurrence of cardiovascular events.Results The levels of BNP,hs-CRP and TnIU1tr in each group of patients were higher than those in the control group,with the differences statistically significant（ P〈 0. 05）. The levels of BNP,hs-CRP and TnIU1tr in group UA,group NSTEMI and group STEMI increased successively; the levels of BNP,hs-CRP and TnIU1tr in single lesion group,double branch disease group and 3 branch disease group increased（ P〈 0. 05）; the levels of BNP,hs-CRP and TnIU1tr in patients with cardiovascular events were higher than those without cardiovascular events,with the differences above all statistically significant（ P 〈0. 05）. Conclusion The levels of BNP,hs-CRP and TnIU1tr are closely related to the severity of acute coronary syndromes with prognostic value.