中波紫外线致皮肤光老化机制及茶叶抗光老化作用研究进展

Mechanisms of ultraviolet b induced skin photoaging and research progress of anti photoaging effect of tea

过量的紫外线照射会引起皮肤的光老化,其中以中波紫外线生物学效应最为明显。皮肤的光老化会导致皮肤临床上和组织学上的多种病变,包括胶原蛋白减少、皮肤变硬、皮层变薄、色素沉积等,并会引起日光性皮炎等多种皮肤相关疾病。中波紫外线诱导皮肤光老化的原因很多,其中最重要的原因是丝裂原活化蛋白激酶(mitogen activated protein kinase,MAPK)通路被激活,引起金属基质蛋白酶(matrix metalloproteinase,MMPs)分泌量增加导致细胞间基质被分解。茶叶作为广为人知的保健饮品,其在抗皮肤光老化方面的作用已得到了证实。茶叶水提物可以通过抑制MAPK磷酸化的途径来预防中波紫外线所致的皮肤光老化症状。文中还对该领域现有研究存在的不足进行了分析,旨在为下一步更全面深入的研究提供研究参考。

Excessive ultraviolet radiation can cause skin photoaging, which is most obvious in the ultraviolet biological effect. Skin photoaging can cause a variety of skin lesions clinically and histologically, including collagen reducing, skin hardening, cortical thinning, and pigment deposition, and cause dermatitis and other skin diseases. Ultraviolet b（UVB） induces skin photoaging for many reasons, the most important reason is that mitogen activated protein kinase（MAPK） pathway is activated, and the increase of secretion of matrix metalloproteinase（MMPs） leads to the decomposition of intercellular matrix. As a widely known health drink, the effect of tea on skin photoaging has been confirmed. Aqueous extract of tea can prevent UVB induced skin photoaging by inhibiting the phosphorylation of MAPK. This paper also analyzed the shortcomings of the existing research in this field, aiming to provide references for the further comprehensive and in-depth researches.