血清Hcy、Cys C及hs-CRP水平检测在动脉粥样硬化中的临床意义

Significance of detection of serum Hcy,Cys C,hs-CRP levels in patients with atherosclerosis

目的分析血清同型半胱氨酸(Hcy)、胱抑素C(Cys C)及超敏C反应蛋白(hs-CRP)水平检测在动脉粥样硬化患者中的临床意义。方法选取动脉粥样硬化患者41例为观察组,经治疗后病情明显好转的动脉粥样硬化患者37例为治疗组,同期选取34例健康体检者为对照组。所选患者均行血清Hcy、Cys C及hs-CRP水平检测,比较三组检测结果。结果观察组血清Hcy、hs-CRP及Cys C水平[(22.16±7.93)μmol/L、(21.01±10.25)mg/L、(1.59±0.47)mg/L]高于对照组[(9.89±3.72)μmol/L,(4.67±1.53)mg/L、(0.72±0.24)mg/L],差异有统计学意义(P<0.05);治疗3、6个月时血清Hcy、hs-CRP、Cys C水平低于治疗前,差异有统计学意义(P<0.05);治疗6个月时,血清Hcy、hs-CRP及Cys C水平低于治疗3个月时,差异有统计学意义(P<0.05)。结论血清Hcy、Cys C及hs-CRP水平检测有助于早期诊断动脉粥样硬化,为治疗效果评价及预后判断提供依据。

Objective To analyze the significance of detection of serum Hcy,Cys C and hs-CRP levels in patients with atherosclerosis. Methods Forty-one patients with atherosclerosis were selected as the observation group,37 atherosclerosis patients with obvious improvement after treatment were selected as treatment group,and 34 healthy persons were selected as the control group at the same time. The levels of serum Hcy,Cys C,hs-CRP were detected and compared. Results The levels of serum Hcy,hsCRP,Cys C in observation group [（ 22. 16 ± 7. 93） μmol/L,（ 21. 01 ± 10. 25） mg/L,（ 1. 59 ±0. 47） mg/L]were significantly higher than those of the control group[（ 9. 89 ± 3. 72） μmol/L,（ 4. 67 ±1. 53） mg/L、（ 0. 72 ± 0. 24） mg/L]（ P 0. 05）; 3 and 6 months after treatment,the levels of serum Hcy,hs-CRP,Cys C were significantly lower than those of patients before treatment（ P 0. 05）; After treatment 6 months,the levels of serum Hcy,hs-CRP,Cys C were significantly lower than those after treatment for 3 months（ P 0. 05）. Conclusions The detection of Hcy,Cys C,hs-CRP levels is beneficial to early diagnosis of atherosclerosis,which can provide basis for evaluation of curative effects and judgment of prognosis.