饮食改善肥胖多囊卵巢综合征患者体内慢性炎症作用的研究进展

Research progress of diet improving chronic inflammation in obese and polycystic ovary syndrome infertility patients

多囊卵巢综合征(PCOS)是典型的生殖障碍性疾病,主要表现为月经稀发、雄激素过多症或高雄激素血症(HA)、卵巢多囊样改变,有关PCOS的发病机制尚无定论,但目前认为PCOS患者体内的慢性炎症状态是发病机制之一。肥胖诱发的炎症可能会引发一连串的事件导致胰岛素抵抗(IR)、血脂异常增加、卵巢雄激素生成增多,最终导致PCOS患者发生生殖障碍。近年流行病学数据表明,饮食中的某些成分可能会影响生殖健康,尤其是与炎症有关的女性生殖疾病,如PCOS。本文根据流行病学和基础研究所见,简要概述慢性炎症在肥胖PCOS患者生殖障碍中的作用,为未来饮食干预肥胖PCOS患者的生殖结局提供依据。

Polycystic ovary syndrome（PCOS） is a typical reproductive disorder characterized by menstrual irregularities, hyperandrogenism and polycystic ovaries. The pathogenesis of PCOS has not been determined, but it is currently believed that the chronic inflammatory state in patients with PCOS is one of the pathogenesis. Obesityinduced inflammation can lead to insulin resistance（IR）, blood lipids abnormal increasing, hyperandrogen, and finally resulted in the occurrence of reproductive disorders in patients with PCOS. Recent epidemiological data show that certain diet ingredients may affect reproductive health, particularly in women with inflammation,such as PCOS. This article is based on epidemiology and research to overview the role of chronic inflammation in the reproductive dysfunction of obese PCOS patients and the function of diet for obesity PCOS patients in reproductive outcomes.