多囊卵巢综合征患者生活方式的调整与减重治疗

Lifestyle intervention and anti-obesity therapies in patients with polycystic ovary syndrome

多囊卵巢综合征(PCOS)是育龄期女性最常见的内分泌及代谢紊乱性疾病之一。生活方式调整包括饮食控制、运动和行为十预,改善超重或者肥胖PCOS患者的代谢和内分泌异常,被推荐为PCOS患者的一线治疗。当生活方式干预联合减重药物治疗时,可对超重/肥胖PCOS患者的内分泌异常改善发挥更有效的作用。奥利司他、二甲双胍和肌醇等药物用于PCOS患者人群,可有效减轻体质量和改善PCOS临床症状,但目前仅有奥利司他获批为减肥适应证药物。此外减重手术也是肥胖PCOS女性的有效治疗手段。本文对生活方式调整和减重药物对PCOS的代谢和内分泌影响的相关研究进行综述。

Polycystic ovary syndrome（PCOS） is a common endocrine and metabolic disorder in women of reproductive age. Lifestyle interventions,including diet, exercise and behavioral modification, improving the metabolic abnormalities of overweight and obese patients with PCOS, are recommended as first-line treatment. Lifestyle interventions combined with anti-obesity products, may exert more effects improving endocrine abnormalities of overweight/obese PCOS patients. Anti-obesity products include orlistat, metformin, and inositol can be effective in decreasing weight or improving PCOS manifestations. However, only orlistat is approved for obesity treatment.Moreover, bariatric surgery is efficient in achieving significant weight loss for obese PCOS women. In the paper, we reviewed and summarized the recently related studies.