血清胱抑素C与冠状动脉斑块的相关性研究

The Relationship Between Serum Cystatin C and Coronary Atherosclerotic Plaque

目的应用冠状动脉CT成像(CTA),探讨血清胱抑素C与冠状动脉粥样硬化斑块的相关性。方法入选2014年1月-2017年5月行CTA检查的200例冠状动脉粥样硬化患者,对冠状动脉狭窄程度、血管病变支数及斑块性质与血清胱抑素C水平进行相关性分析。结果血清胱抑素C水平与冠状动脉的狭窄程度(轻度、中度、重度)、血管病变支数(单支、双支、三支)、斑块性质(稳定性斑块、不稳定性斑块)相关,差异有统计学意义(P<0.05)。年龄>65岁、糖尿病、血清胱抑素C≥1.40 mg/L均为影响冠状动脉粥样硬化斑块的独立危险因素(P<0.05)。结论血清胱抑素C水平有助于预测冠状动脉粥样硬化斑块的病变状况。

Objective Application of CT coronary angiography （CTA）, to investigate the correlation between serum cystatin C and coronary atherosclerofic plaque. Methods Selected from January 2014 to May 2017 in Changzhou Fourth People＇s Hospital in 200 cases of coronary atherosclerosis in patients with CTA examination, the degree of coronary artery stenosis, vascular lesions and the correlation analysis of plaque and serum level of cystatin C the degree of stenosis. Re- suits The serum level of cystatin C and coronary artery （ mild, moderate, severe） , the number of vascular lesions （ sin- gle, double, three）, plaque stability （plaque instability Qualitative plaque）, the difference was statistically significant （P 〈 0. 05）. 〉 65 years of age, diabetes, independent risk factors of serum cystatin C = 1.40 mg/L were coronary ath- erosclerotic plaque （P 〈 0.05）. Conclusions The changes of serum cystatin C levels contribute to the prediction of coronary atherosclerotic plaque.