银杏叶片对不稳定型心绞痛患者MPA、CD11b及MCP-1水平的影响

Effects of Ginkgo biloba tablet on MPA,CD11b and MCP-1 levels in patients with unstable angina pectoris

目的:观察银杏叶片治疗的不稳定型心绞痛(UAP)患者单核细胞-血小板聚集体(MPA)及单核细胞活化指标水平的变化,探讨其对心血管疾病的治疗机制。方法:测定92例UAP和42例稳定性心绞痛(SAP)患者外周血MPA、CD11b和单核细胞趋化蛋白-1(MCP-1)水平,将UAP患者随机分为常规治疗组(对照组)和合并银杏叶片治疗组(银杏叶组),同时在治疗28 d后评估治疗效果并测定MPA、CD11b和MCP-1水平。结果:UAP组MPA、CD11b和MCP-1水平均显著高于SAP组(t=18.514,23.301和22.523,P<0.01)。MPA与CD11b水平和MCP-1浓度均成正相关(r=0.626和0.635,P<0.01)。银杏叶片治疗的总有效率(76.1%,35/46)显著高于常规治疗者(56.5%,26/46)(P<0.05)。银杏叶组治疗后MPA、CD11b和MCP-1水平均显著低于对照组(P<0.01)。银杏叶治疗总有效组在治疗后三者水平均显著低于治疗前(P<0.01),总有效组各指标水平降低率显著高于总无效组(P<0.01)。结论:银杏叶片可通过下调MPA、CD11b和MCP-1水平从而有效治疗UAP。

AIM： To observe the levels of monocyte-platelet aggregates（ MPA） and markers of activated monocytes in patients with unstable angina pectoris（ UAP） accepting Ginkgo biloba tablet treatments,and to explore its mechanisms for cardiovascular disease treatments.METHODS： The levels of MPA,CD11b,and MCP-1 were measured in92 unstable angina pectoris（ UAP） and 42 stable angina pectoris（ SAP）.The UAP patients were randomly assigned into routine treatment group（ control group） and combined tablet treatment group（ Ginkgo biloba group）.The efficacy was assessed,and the levels of MPA,CD11b,and MCP-1 were measured after 28 days of treatment,respectively.RESULTS： The levels of MPA,CD11b,and MCP-1 in UAP group were higher than those in SAP group（ P〈0.001）.The levels of MPA and CD11b were positively correlated with MCP-1 level（ P〈0.01）.The total rate of effective Ginkgo biloba tablet treatment was higher than that of non-Ginkgo biloba tablet treatment（ P〈0.05）.After 28 days of treatments,the levels of MPA,CD11b,and MCP-1 in Ginkgo biloba group were significantly lower than those in control group（ P〈0.001）.In total effective treatment group,the levels of MPA,CD11b,and MCP-1 were significantly lower after treatment than those before treatment（ P〈0.001）,and the decreased rates of these markers after treatment were also much higher（ P〈0.01）.CONCLUSION：There is an obvious efficacy of Ginkgo biloba tablet on unstable angina pectoris by down-regulating the levels of MPA,CD11b and MCP-1.