1例胺碘酮合用莫西沙星致QTc间期延长并发尖端扭转型室速的病例分析

QTc interval prolongation complicated by torsade de pointes induced by amiodarone and moxifloxacin: a case report

目的:探讨QTc延长并发尖端扭转型室速的原因,为临床用药的安全性提供参考。方法:临床药师参与1例胺碘酮合用莫西沙星致QTc间期延长并发尖端扭转型室速的治疗,分析不良反应发生的原因及处理方法。结果:此次不良反应可能与胺碘酮和莫西沙星有关,该患者危险因素较多,临床用药时应加强用药安全的监督。结论:临床使用胺碘酮联用莫西沙星时,临床药师应掌握药物相互作用,加强药学监护,提高用药安全性。

Objective： To investigate the causes of QTc interval prolongation complicated by torsade de pointes, and to provide reference for drug safety. Methods： Clinical pharmacists participated in the treatment and causes analysis for a patient with QTc interval prolongation complicated by torsade de pointes induced by amiodarone and moxifloxacin. Results： The adverse effect might be related to amiodarone and moxifloxacin, the clinical drug monitoring should be strengthened on this patient with many risk factors. Conclusion：Drug-drug interactions should be recognized by clinical pharmacists as amiodarone combined with moxifloxacin. The pharmaceutical care should be strengthened for improving drug safety.