uNGAL对老年患者体外循环下冠状动脉搭桥术后急性肾损伤预测的临床研究

uNGAL Detection for Diagnosis of Acute Kidney Injury after Old Age Cardiopulmonary Bypass

目的观察并分析尿中性粒细胞明胶酶相关脂质运载蛋白(neutrophil gelatinase-associated lipocalin,uNGAL)在老年患者冠状动脉搭桥术后急性肾损伤(acute kidney injury,AKI)诊断中的价值与意义。方法选择43例进行体外循环手术的老年(≥70岁)冠心病患者,将患者分为AKI组(11例)及非AKI组(32例)。分别留取不同时间的尿液,ELISA法检测uNGAL,同时分析当时血清肌酐水平。结果术后2d内有11例发生不同程度AKI,AKI组在体外循环术后各时间点uNGAL浓度都显著升高,两组比较有显著性差异。结论 uNAGL可以作为老年搭桥体外循环术后AKI的预测指标,诊断上要早于血肌酐,有利于对AKI进行早期诊治。

Objective To observe and analyze the value of Urine neutrophil gelatinase—associated lipocalin（uNGAL）detection for diagnosis of acute kidney injury（AKI）after old age cardiopulmonary bypass. Method Selection of 43 case of coronary heart disease in elderly patients undergoing cardiopulmonary bypass in this prospective study. The patients were divided into group（32 cases） AKI and non AKI group（ll cases）,Leave urine for different times, Serial urine samples were analyzed by ELISA for evaluating NGAL expression. The level of serum creatinine was analyzed at the same time. Result 2 days after the operation, 11 cases had different degrees of AKI.In group AKI, the concentration of uNGAL increased significantly at every time point afer cardiopulmonary bypass. There are significant differences between the two groups.Conclusion Concentrations in u NGAL represent sensitive, specific, and highly predictive early biomarkers for acute renal injury after old age cardiopulmonary bypass.