葡萄膜黑色素瘤预后因素的研究

The prognostic factors of uveal melanoma

葡萄膜黑色素瘤（uvealmelanoma，UM）主要来源于葡萄膜黑色素细胞，是成年人最常见的眼内恶性肿瘤，预后差。其转移是导致该病高死亡率的主要原因，发生血行转移的概率可高达50％。UM的预后与临床组织病理学高危因素、基因表达谱、染色体畸变以及基因突变等因素相关，相关程度有所差异。探索UM高相关性的预后因素是评估UM转移的风险大小、无病生存期的重要方向，从而进一步为患者是否保留眼球以及个体化治疗提供科学依据。

Uveal melanoma （UM） is mainly derived from uveal melanocytes, which is the most common intraocular malignant tumor in adult. The prognosis of UM is poor. The main cause of high mortality of UM patients is metastasis. The probability of hematogenous metastasis can be as high as 50%. The asso- ciation of UM prognosis include clinical pathological features, genetic mutations, chromosome aberrations and gene expression profiles. It is an important research direction to explore the correlated prognostic factors of UM patients for assessing the risk of UM metastasis and disease-free survival. This provides a scientific basis to judge whether the patient could retain the eyeball and to select individualized treatments.