上皮间质转化的表观遗传调控

Epigenetic regulation of epithelial-mesenchymal transition

E-钙黏蛋白（E-cadherin）表达丧失是上皮间质转化（EMT）的重要标志，许多EMT转录因子结合到E-cadherin启动子区下调其表达，从而调节EMT。表观遗传调控包括DNA甲基化、组蛋白修饰、微小RNA，均参与EMT相关基因表达调控。研究表明，EMT转录因子协同表观遗传调控因子参与E-cadherin表达。靶向EMT表观调控代表着肿瘤新的治疗方向。

The hallmark of epithelial-mesenchymal transition （EMT） is the loss of E-cadherin. The downregulation of E-cadherin can he mediated by its transcriptional repression through the binding of EMT tran- scription factors to the E-eadherin promoter. Epigenetie mechanisms including DNA methylation, histone code and microRNAs are involved in the regulation of EMT-related genes. Studies have shown that EMT transcription factors can cooperate with several epigenetic modifiers to participate in the expression of E-cadherin. Targeting epigenetie regulation of EMT represents a new promising therapeutic direction.