自噬与白血病多药耐药

Autophagy and multidrug resistance

多药耐药（MDR）是白血病化疗失败的主要原因。自噬在调控MDR中发挥重要作用。一方面，自噬作为程序性死亡机制能直接促进MDR细胞凋亡；另一方面，不同信号传导通路和诱导因子如Hedgehog（Hh）信号通路、p53可诱导保护性自噬，促进MDR细胞的存活。因此，自噬激动剂或自噬抑制剂联合化疗药物有望成为治疗白血病的新策略。

Muhidrug resistance （MDR） is the main reason for the failure of leukemia chemotherapy. Autophagy plays an important role in the regulation of MDR. On one hand, as a mechanism of programmed cell death, autophagy can directly induce the death of MDR cells. On the other hand, protective autophagy induced by different signaling pathways and factors such as Hedgehog （Hh） signaling pathway and p53 can promote the survival of MDR cells. Therefore, autophagy agonist or autophagy inhibitors combined with chemotherapeutics will be a new strategy for the treatment of leukemia.