陕西省女性宫颈HPV感染流行病学现状调查

Epidemiological status of cervical HPV infection in women in Shaanxi province

目的调查陕西省女性宫颈人乳头瘤病毒(HPV)感染状况,为制定宫颈癌防治政策提供理论依据。方法根据2012年陕西省统计局提供的人口数据,对关中、陕南、陕北地区进行随机调查抽样,采用表面等离子共振(SPR)技术对2012年3月至2015年12月间所有抽样人群进行HPV定量分型检测,分析陕西省HPV的感染状况。结果在38 408例患者中共检出7 723例HPV阳性者,阳性率为20.11%;其中高危HPV(HR-HPV)阳性有6 815例,阳性率为17.74%。在检出的24种HPV亚型中,按感染率由高到低排列分别为16、58、52、18、53、56、61、39、51、59、55、66、33、6、35、82、11、31、42、44、45、40、26、68亚型。不同年龄段HR-HPV感染率不同,以≤25岁年龄段感染率最高(24.39%),其次为≥56岁年龄段(20.38%),26~35岁年龄段感染率最低(15.69%)。HR-HPV感染中以单一感染为主(81.92%),多重感染中以二重感染最常见(15.84%)。结论 HPV感染在陕西省呈现单一、高危亚型感染为主的特征,该地区应重视HPV16、58、52、18、53型持续性感染的防治。

Objective To investigate cervical human papilloma virus（HPV）infection status in women in Shaanxi province and to provide evidence for formulation of cervical cancer prevention policy.Methods Random sampling was implemented in central,southern and northern Shaanxi areas based on demographic data provided by Shaanxi Provincial Bureau of Statistics in 2012.Quantitative detection and typing of HPV in population sampled from March 2012 to December 2015 was carried out using surface plasmon resonance（SPR）technique.HPV infection status in Shaanxi was analyzed.Results There were 7 723 HPV positive cases in 38 408 sampled people,showing positive rate of 20.11%,and among them 6 815 cases were high risk HPV（HR-HPV）,which positive rate was 17.74%.Twenty-four HPV subtypes detected were 16,58,52,18,53,56,61,39,51,59,55,66,33,6,35,82,11,31,42,44,45,40,26,68 in turn with infection rate from high to low.Infection rate of HR-HPV in various age groups was different.Infection rate in samples less than 25 years（24.39%）was highest,followed by samples older than 55 years（20.38%）,and infection rate in samples in 26-35 years（15.69%）was lowest.The most common types of HR-HPV infection were single infection（81.92%）,and double infections were most common in multiple HPV infections（15.84%）.Conclusion Prevalence of HPV infection in Shaanxi is mainly single and high risk subtype HPV infection.It is necessary to focus on prevention of HPV 16,58,52,18 and 53 subtype persistent infection in this region.