某院新疆地区的维吾尔族、哈萨克族人群Kell血型基因频率调查

Investigation of the Kell blood group gene frequency in one hospital of Uygur and Kazak population in Xinjiang,China

目的对某院新疆地区的维吾尔族、哈萨克族人群Kell血型基因频率调查,并对输血和妊娠中产生输血不良反应风险进行评估。方法利用单克隆血清检测红细胞Kell血型系统中K和k抗原。筛选方法采用盐水介质直接离心和抗人球蛋白试验。结果在调查914人中,维吾尔族757人,哈萨克族157人。在维吾尔族人群中筛选到Kel(1-2+)742例,Kel(1+2+)15例,未检测到Kel(1+2-)表现型;在哈萨克族人群中筛选到Kel(1-2+)153例,Kel(1+2+)4例,未检测到Kel(1+2-)表现型。维吾尔族K基因频率为0.009 9,k基因频率为0.990 1;哈萨克族K基因频率为0.012 7,k基因频率为0.987 3。结论新疆维吾尔族和哈萨克族K基因频率有差异,并具有各自特点。

Objective To investigate the gene frequency of Kell blood group in one hospital of Xinjiang Uygur and Kazak population,and to evaluate the risks of adverse transfusion reactions,especially in pregnancy. Methods The K and k antigens of the Kell blood system on the surface of erythrocytes were detected with monoclonal serum. The screening were performed using direct saline media centrifugationand the Coombs＇ test. Results A total of 914 blood cases were analyzed including 757 Uygur individuals and 157 Kazak individuals. The Uygur population presented 742 cases of the Kel（ 1-2＋） phenotype and 15 cases of Kel the（ 1＋ 2＋） phenotype while no Kel（ 1＋ 2-） phenotype was not detected. The Kazak,on the other hand,presented 153 cases of the Kel（ 1-2＋） phenotype and 4 cases of the Kel（ 1＋2＋） phenotype while the Kel（ 1＋2-） phenotype was not found either. In the Uygur population,the frequencies of the K and the k gene were 0. 009 9 vs0. 990 1. In the Kazak population,the frequencies of the K and the k gene were 0. 012 7 vs 0. 987 3. Conclusion The frequencies of the K gene in Xinjiang Uygur and Kazak population differs and each group possesses its own characteristics.