佛山市三水区儿童血流感染病原菌分布及耐药性分析

Distribution and antibiotic resistance analysis of pathogenic bacteria in children with blood stream infection in Sanshui District Foshan city

目的：分析我院血流感染病原菌分布及耐药情况，指导临床合理使用抗菌药。方法：回顾性分析2015年1月-2017年3月血培养分离出的病原菌和耐药性。结果：血培养总例数为158例，分离得到病原菌76株，其中，革兰氏阳性菌株以凝固酶阴性葡萄球菌为主，共检测到27株（占32．1似）；革兰氏阴性菌株以大肠埃希菌为主，共检测到20株（占26．32％）。耐药性分析显示凝固酶阴性葡萄球菌主要对青霉素耐药，而万古霉素、亚胺培南和利奈唑胺具有较高的抗菌活性，大肠埃希菌对头孢菌素类耐药率较高。结论：我院血培养中分离的病原菌多耐药现象比较多见，临床上应对血培养给予高度重视，根据药敏结果应用抗生素，并加强耐药性监测管理。

Objective： To analyze the distribution and drug resistance of bacterial pathogens in blood stream infection, so as to guide the rational use of antimicrobiai agents. Methods： The pathogens isolated from blood culture arid their microbial susceptibility tests from January 2015 to March 2017 were analyzed retrospectively. Results： 76 strains of pathogens were isolated from a total number of 158 blood culture specimen. The majority of gram positive bacteria were coagulase negative staphylococci, 27 strains were isolated （32.14%） . The majority of gram negative bacteria were Escherichia coli, 20 strains were isolated （26.32%） . Microbial susceptibility tests showed that coagulase negative staphylococci were mainly resistant to penicillin, but susceptible to vancomycin, imipenem and linezolid. The resistant ratio of Escherichia coil to cephalosporins was high. Conclusion： More attention should be paid to the common drug resistance of the pathogens isolated from blood culture in our hospital. Antibiotics should be used according to the antirnicrobial susceptibility tests and the surveillance should be reinforced.