阿托品对氯胺酮小鼠催眠、镇痛、学习记忆的影响

Effects of Atropine on Hypnosis,Analgesia,Learning and Memory in Ketamine Mice

目的:分析阿托品对氯胺酮小鼠催眠、镇痛、学习记忆的影响,以指导临床用药。方法:随机分小鼠80只为四组,每组各20只,各自使用相应方法,每组再划分NS组、At组、Ket组、At+Ket组,每组5只。各小组分别腹腔注射相关药物和生理盐水,并进行观察。结果:跳台与避暗的实验表明,阿托品不会影响小鼠的学习记忆。氯胺酮的镇痛作用比较明显(P<0.05),阿托品则无以上作用。结论:阿托品对氯胺酮影响小鼠催眠、镇痛、学习记忆。氯胺酮短时间诱导,能够彻底镇静与镇痛,被用作分离麻醉剂;同时氯胺酮能增加呼吸道与唾液的分泌量,不能确保呼吸道的顺畅。阿托品是M胆碱受体阻滞剂,对腺体分泌起到阻碍作用。

Objective： To explore the effects of atropine on hypnosis,analgesia,learning and memory in ketamine mice. Methods： Eighty rats were randomly divided into four groups and 20 rats in each group. The rats were divided into NS group,At group,Ket group and At ＋ Ket group. Each group were intraperitoneally injected intraperitoneal injection of related drugs and saline,which were observed. Results： The experiment showed that atropine did not affect the learning and memory of mice. The analgesic effect of ketamine was obvious（ P〈 0. 05）,and atropine had no effect. Conclusion：Atropine affects ketamine in mice hypnosis,analgesia,learning and memory. Ketamine for a short time to induce,complete sedation and analgesia,was used as an isolated anesthetic; increase the secretion of respiratory and saliva,can not ensure the smooth breathing. Atropine is a M-choline receptor blocker, which inhibits glandular secretion. At present,there were few report about Anesthesia before the use of atropine,ketamine,and whether the impact of anesthesia. The purpose of this experiment is to guide clinical medication.