黛力新辅助治疗胃食管反流病的疗效观察及对患者睡眠质量的影响

The Observation of Curative Effect of Deanxit in the Treatement of Gastroesophageal Reflux Disease and the Influence on Sleep Quality

目的:黛力新辅助治疗胃食管反流病的疗效观察及对患者睡眠质量的影响。方法:选取2015年12月~2017年1月于我院消化科治疗的120例胃食管反流病的患者作为研究对象,随机分为观察组60例,对照组60例。对照组给予埃索美拉唑+莫沙必利+氢氧化铝凝胶治疗;观察组在对照组的基础上加用黛力新治疗。比较2组疗效及对患者睡眠质量的影响。结果:观察组治疗的有效率与对照组相比较,明显高于后者;观察组焦虑量表评分(HAMA)和抑郁量表评分(HAMD)明显低于对照组;观察组睡眠困难发生率明显低于对照组(P<0.05)。观察组不良反应发生率与对照组相比较,差异不具有统计学意义(P>0.05)。结论:黛力新辅助治疗胃食管反流病,临床疗效较好,且能改善患者焦虑、抑郁情绪和睡眠状况,值得在临床进一步探讨和推广。

Objective： Efficacy of Deanxit in the treatment of gastroesophageal reflux disease and its influence on sleep quality. Methods： 120 patients with gastroesophageal reflux disease treated in our hospital from December 2015 to January ~ 2017 were selected and randomly divided into the observation group（ 60 cases） and the control group（ 60 cases）. The control group was given esomeprazole plus mosapride ＋ Aluminium Hydroxide Gel treatment; the observation group was treated with Deanxit on the basis of the control group. The therapeutic effects of the two groups were compared.Results： Compared with the control group,the effective rate of the observation group was significantly higher than that of the control group. The score of anxiety scale（ HAMA） and Depression Scale（ HAMD） in the observation group were significantly lower than that of the control group. The incidence of sleep difficulty in the observation group was significantly lower than that of the control group（ P〈 0. 05）. The incidence of adverse reactions in the observation group was not statistically significant compared with the control group（ P〉 0. 05）. Conclusion： Deanxit in the treatment of gastroesophageal reflux disease has good clinical efficacy,and can improve the anxiety,depression and sleep status of patients. It is worthy of further exploration and promotion in clinical practice.