摘要
阿尔茨海默病(Alzheimer disease,AD)是最常见的痴呆类型之一。5-羟色胺(5-HT)受体介导的信号通路在AD发病过程中扮演着重要的角色,可通过调节胆碱能和谷氨酸能神经传递,改变认知能力,调节学习记忆功能。AD患者常伴发抑郁、淡漠等情绪问题和无节制饮食等临床表现,上述症状均与5-HT受体介导的功能有关。增强5-HT受体介导的信号通路及研发增加突触间5-HT浓度的药物,已作为新的延缓AD疾病进展的治疗策略。本文以5-HT转导通路为目标的AD治疗策略作一综述。
Alzheimer disease（AD）is one of the most common types of dementia.Serotonin（5-HT）plays an important role in the pathogenesis of AD,causing alterations in patients＇ cognitive abilities,as well as learning and memory capabilities,by regulating the cholinergic and glutamatergic neurotransmission through the signal transduction pathway.Patients suffer from emotional disorders including depression and apathy and clinical manifestations such as unrestrained diet,which are all related to the signaling function of 5-HT receptors.Strengthening the 5-HT receptor-mediated transduction pathway and increasing the concentration of synaptic 5-HT have been used as a novel therapy for delaying the progression of AD.This articles reviews the AD therapies targeting 5-HT transduction pathway.
出处
《中国临床医学》
2017年第6期964-969,共6页
Chinese Journal of Clinical Medicine
基金
国家自然科学基金(81171252,81070070,81371459,30900473)
国家科技部十二五重大专项(2011ZXJ09202-015)
国家科技支撑计划项目(2015BAI13B01)
上海市自然科学基金(15ZR1414600)
上海市科委“科技创新行动计划”(17411950104)~~
