富含血小板血浆支架在年轻恒牙牙髓血运重建术中的应用

Analysis of pulp revascularization of immature permanent teeth with PRP

目的 探讨不同支架在牙髓血运重建术中的应用效果.方法 选择根尖周病变的年轻恒牙患者22例,采用随机数字表法分为观察组和对照组各11例.经过完善根管消毒后,对照组采用诱导根尖出血形成血凝块的方法进行牙髓血运重建术,观察组取患者自体血获得富含血小板血浆（PRP）行牙髓血运重建术.结果 对照组2例分别于术后1、8个月出现疼痛;3例术后12、18个月复诊发现根尖周病变区明显减小,根尖孔减小;6例术后12、18个月复诊发现根尖周病变愈合,牙根长度明显变长,根尖孔闭合.观察组3例分别于术后1、3、18个月出现疼痛;4例术后12、18个月复诊发现根尖周病变区明显减小,根尖孔减小;4例术后12、18个月复诊发现根尖周炎性透射影消失,根尖孔闭合;经Fisher确切概率法计算分析,观察组与对照组差异无统计学意义（P=1.000）.结论 富含血小板血浆支架是牙髓血运重建术中的一种效果良好的支架,可广泛推广.

Objective To discuss the clinical effect of different scaffold in pulp vascular regeneration . Methods 22 young permanent teeth with periapical lesions were randomly divided into observation group and control group,11cases in each group .After the disinfection protocol was completed , the apexes of the control group were irritated to initiate bleeding to produce a blood clot to achieve pulp revascularization ,while the observation group used platelet rich plasma as physical scaffold to operate pulp revasculrization .Results In the control group , the two patients showed painful tooth at 1 and 8 months,the three patients showed healed periapical lesions and narrowed apical foramen at 12 and 18 months ,the six patients showed healed periapical lesions and closure of the apical fora -men at 12 and 18 months.In the observation group ,the three patients showed painful tooth at 1,3 and 8 months,the four patients showed healed periapical lesions and narrowed apical foramen at 12 and 18 months,the four patients showed healed periapical lesions and closure of the apical foramen at 12 and 18 months.There was no statistically significant difference between the observation group and control group by Fisher＇s exact probabilities （P=1.000）. Conclusion Platelet rich plasma is potentially an ideal scaffold for pulp revascularization .