美沙拉嗪联合马来酸曲美布汀治疗腹泻型肠易激综合征疗效观察

Curative effect of mesalamine combined with trimebutine maleate in the treatment of diarrhea predominant irritable bowel syndrome

目的 探讨美沙拉嗪联合马来酸曲美布汀治疗腹泻型肠易激综合征疗效.方法 选取112例腹泻型肠易激综合征的患者,采用随机数字表法分为对照组和观察组,每组56例.两组均给予常规的药物对症治疗,在此基础上,对照组使用美沙拉嗪治疗,观察组使用美沙拉嗪联合马来酸曲美布汀治疗,两组均连续治疗4周.比较两组患者主要指标变化、临床疗效、生活质量评分及不良反应等.结果 观察组总有效率为94.6％,与对照组的78.6％比较,差异有统计学意义（χ^2=3.925,P〈0.05）;观察组止泻时间、大便性状复常时间与对照组比较,差异均有统计学意义（t=19.337、18.068,均P〈0.05）;两组精神状态、情绪状况、饮食状况及睡眠状况评分较治疗前均有所改善,差异均有统计学意义（均P〈0.05）,但观察组改善程度显著优于对照组,差异均有统计学意义（均P〈0.05）;两组均未出现其他严重的不良反应.结论 在常规治疗的基础上加用美沙拉嗪联合马来酸曲美布汀对腹泻型肠易激综合征进行治疗,可显著改善临床症状,提高临床疗效,且安全性较好,具有较大的临床借鉴意义.

Objective To investigate the curative effect of mesalamine combined with trimebutine maleate in the treatment of diarrhea predominant irritable bowel syndrome .Methods According to the digital table ,112 patients with diarrhea predominant irritable bowel syndrome were randomly divided into control group and observation group , 56 cases in each group .The two groups were given conventional symptomatic treatment ,on this basis ,the control group recieved mesalamine treatment ,the observation group recieved mesalamine combined with trimebutine maleate treat -ment.The two groups were treated for 4 consecutive weeks.The main indicators,clinical efficacy and adverse reaction of the two groups were compared .Results The total effective rate of the observation group was 94.6%,which was significatnly higher than 78.6%of the control group （χ^2 =3.925,P〈0.05）.The antidiarrheal time,stool recovery time between the two groups had statistically significant differences （t=19.337,18.068,all P〈0.05）.The mental status,emotional status,diet and sleep status in the two groups were all improved ,the differences were statistically significant（all P〈0.05）,which in the observation group improved more significantly than that in the control group , the differences were statistically significant（all P〈0.05）.The two groups had no other serious adverse reactions . Conclusion On the basis of conventional treatment ,mesalamine combined with trimebutine maleate in the treatment of diarrhea predominant irritable bowel syndrome can significantly improve clinical symptoms ,improve clinical curative effect,and it has good safety and great clinical significance .