巴戟天寡糖胶囊联合心理辅导治疗产后抑郁疗效研究

Clinical effect of Morinda officinalis How oligosaccharide capsule combined with psychological therapy in the treatment of postpartum depression

目的观察巴戟天寡糖胶囊联合心理辅导治疗产后抑郁的临床疗效。方法将明确诊断为产后抑郁的60例患者按照入组先后顺序随机分为治疗组（巴戟天寡糖胶囊联合心理辅导）和对照组（单用心理辅导）各30例，进行开放、随机、对照研究。治疗前及治疗2、4、6周末，均通过汉密尔顿抑郁量表（HAMD）和中医肾虚症量化评分量表减分率评价疗效；采用药物不良反应症状量表（TESS）评价不良反应。结果治疗前两组HAMD和中医肾虚症量化评分量表评分差异无统计学意义（P〉0．05）；治疗后，两组HAMD和中医肾虚症量化评分量表的减分值差异均有统计学意义（均p〈0．05）；治疗后两组HAMD和中医肾虚症量化评分量表的有效率（减分值≥25％）分别为67．62％和70．00％，两组比较差异有统计学意义（P〈0．01）；两组不良反应发生率比较差异无统计学意义（P〉0．05）。结论巴戟天寡糖胶囊联合心理辅导治疗产后抑郁，临床效果显著，不良反应小，是一种值得推广的治疗方案。

Objective To observe the clinical effect of Morinda officinalis How oligosaccharide capsule （MOs） combined with psychological therapy in the treatment of postpartum depression. Methods 60 patients with postpartum depression were randomly divided into two groups,30 cases in each group. The control group was adopted the psychological therapy, and the observation group received combined treatment of MOs and psychological therapy. The HAMD - 17 and Chinese medicine scale for the quality of kidney deficiency syndrome（CMSKDS） were used to assess the treatment effect after 2,4,6 weeks treatment. The TESS was adopted to evaluate the side effect of treatment. Results There were no statistically significant differences between the two groups on HAMD and CMSKDS before treatment （ all P 〉 0.05 ）. After treatment, the effective rates of HAMD and CMSKDS （ reducing score ≥ 25 % ） of the two groups were 67.62% （ control group） and 70.00% （ observation group） ,the defferences between the two groups were statistically significant （ all P 〈 0.01 ）. There was no statistically significant difference in TESS result （ P 〉 0. 05）. Conclusion The clinical effect of combined MOs and psychological therapy in the treatment of postnatal depression is remarkable,with little side effect,which can be strongly recommended.