复方甘草酸苷治疗酒精性脂肪肝效果观察

Effect of compound glycyrrhizin on alcoholic fatty liver disease

目的观察复方甘草酸苷治疗酒精性脂肪肝的临床效果。方法选择酒精性脂肪肝患者68例，按照治疗方法不同分为两组，对照组34例采用常规治疗，观察组34例在常规治疗基础上应用复方甘草酸苷治疗。比较两组临床疗效。结果观察组总有效率为91．18％，高于对照组的64．71％，差异有统计学意义（χ^2=6．928，P〈0．05）。治疗后，观察组总胆红素（TBIL）、谷氨酰转肽酶（GGT）、天门冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）分别为（6．39±1．15）p．moL／L、（157．79±17．39）U／L、（37．49±2．61）U／L、（24．45±2．16）U／L，对照组分别为（26．14±2．79）Ixmo／／L、（417．59±45．89）U／L、（97．28±11．39）U／L、（54．33±4．05）U／L，两组差异均有统计学意义（t=41．392、33．482、32．361、41．171，均P〈0．05）。观察组不良反应发生率为5．88％，低于对照组的26．47％（χ^2=4．250，P〈0．05）。结论与常规治疗比较，复方甘草酸苷治疗酒精性脂肪肝，能有效改善患者TBIL、GGT、AST、ALT指标，提高临床疗效。

Objective To observe the clinical effect of compound glycyrrhizin in the treatment of alcoholic fatty liver disease（AFLD）. Methods 68 AFLD patients according to the different treatment methods were divided into two groups. 34 cases in the control group received conventional therapy, 34 cases in the observation group were given compound glycyrrhizin based on the conventional treatment. The clinical effect of the two groups was compared. Results The total effective rate of the observation group was 91.18 %, which was higher than 64.71% of the control group, the difference was statistically significant （χ^2= 6. 928, P 〈 0.05 ）. The TBIL, GGT, AST, ALT of the observation group were （6.39 ± 1.15 ） μmolfL, （ 157.79 ± 17.39） U/L, （37.49 ± 2.61 ） U/L, （24.45 ± 2. 16） U/L, respectively, which of the control group were （26.14 ± 2.79） μmol/L, （417.59 ± 45.89） U/L, （ 97.28 ± 11.39 ） U/L, （ 54.33 ± 4.05） U/L, respectively, the differences between the two groups after treatment were statistically significant （t = 41. 392,33. 482,32. 361,41. 171, all P 〈 0.05 ）. The incidence rate of adverse reactions of the observation group was 5.88% ,which was lower than 26.47% of the control group（χ^2 =4. 250,P 〈0.05）. Conclusion Compared with conventional treatment, compound glycyrrhizin in the treatment of AFLD ean effectively improve the patients＂ TBIL, GGT, AST, ALT index, improve the clinical efficacy.