药物代谢模型在创新药物研究中的应用进展

Application progress of drug metabolism model in the innovative drug research

综述药物代谢模型研究现状。检索数据库相关文献，分析、汇总。药物代谢模型多种，机制多样。各模型均有其自身的优缺点，研究者应根据研究目的和实验室现有条件先行体外实验，对体外代谢特性良好的化合物进一步的进行体内实验，以对药物代谢特性作出合理准确的预测。

To review the current status of drug metabolism model. To retrieve, analyze and summarize me relevant literatures of the database. There are many kinds of drug metabolism models and mechanisms. Every model has its own advantages and disadvantages. The researchers should use in vitro experiments based on the purpose of the study and the existing laboratory conditions. If the compounds have good metabolic properties in vitro, they can be further tested in vivo to make a reasonable and accurate prediction for drug metabolic properties.