摘要
目的:探讨短暂性脑缺血(transient ischemic attack,TIA)患者用药的依从性对其预后的影响。方法:将2010年1月至2012年6月某医院神经内科病房收治的400例TIA患者作为研究对象。在这些患者病情稳定出院后对其进行5年的随访,观察其病情的复发率及心肌梗死、脑卒中的发生率。结果:在5年内这400例患者使用抗血小板药的依从率为57.26%,其使用抗栓药的依从率为41.9%,其使用降压药、降糖药、调脂药的依从率在33%~36%之间,其使用抗凝药的依从率为24.39%。预后不良组患者与预后良好组患者使用降压药、降糖药、调脂药、抗血小板药、抗栓药、抗凝药的依从性相比较,差异有统计学意义(P<0.05)。进行Logistic回归分析的结果显示,使用降糖药、降压药、调脂药、抗凝药、抗血小板药、抗栓药的依从性均是影响本研究中患者预后的独立因素。结论:TIA患者应用降糖药、降压药、调脂药、抗凝药、抗血小板药、抗栓药的依从性是影响其预后的独立因素。促使TIA患者严格遵医嘱使用上述药物进行治疗可显著改善其预后。
objective： to study the transient ischemic（transient ischemic attack, TIA） in patients with medication adherence on its prognosis. Methods： Select 400 cases of patients with TIA in a neurology hospital during January 2010 to June 2012 for research object. In these patients in stable condition after discharge for 5 years of followup, observe the condition of the recurrence rate and the incidence of myocardial infarction, stroke,. Results： 400 cases in 5 years the use of antiplatelet drug compliance rate was 57.26%, the use of antithrombotic drug compliance rate was 41.9%, the use of blood pressure, diabetes, lipid drug compliance rate is between 33% ~ 36%, the use of anticoagulants compliance rate was 24.39%. Prognosis of patients with good prognosis group patients with blood pressure, diabetes, lipid drug, antiplatelet drugs, antithrombotic drugs, in comparison with the compliance of anticoagulant drugs, the difference was statistically significant（P〈0.05）. The Logistic regression analysis results show that, the use of medications, blood pressure, lipid, anticoagulants and antiplatelet drugs, antithrombotic drug adherence are the independent factors affecting the prognosis of patients with this study. Conclusion： patients with TIA application medications, blood pressure, lipid, anticoagulants and antiplatelet drugs, antithrombotic drug adherence is independent factors influencing its prognosis. Get TIA patients use strictly prescribed the drug treatment can significantly improve its prognosis.
