用不同剂量的米非司酮对围绝经期功血患者进行治疗的效果对比

Analysis of different doses of mifepristone on perimenopausal dysfunctional uterine bleeding effect and endocrine function influence

目的:对比分析用不同剂量的米非司酮对围绝经期功能失调性子宫出血(围绝经期功血)患者进行治疗的临床效果。方法:将2015年1月至2017年1月江油市人民医院妇产科收治的104例围绝经期功血患者根据用药方案的不同分为试验组与对照组。为对照组患者使用较大剂量的米非司酮进行治疗,为试验组患者应用较小剂量的米非司酮进行治疗,然后对比分析两组患者血液中黄体生成激素、卵泡刺激素、雌二醇、孕酮的水平、临床疗效及发生不良反应的情况。结果:与进行治疗前相比,对两组患者进行治疗后其血液中黄体生成激素、卵泡刺激素的水平无明显的变化(P>0.05),其雌二醇、孕酮的水平均较低,差异有统计学意义(P<0.05)。与对照组患者相比,试验组患者在进行治疗后其雌二醇、孕酮的水平均较低,差异有统计学意义(P<0.05)。与对照组患者相比,试验组患者治疗的总有效率较高,差异有统计学意义。试验组患者不良反应的发生率低于对照组患者,差异有统计学意义(P<0.05)。结论:与使用大剂量的米非司酮相比,使用小剂量的米非司酮对围绝经期功血患者进行治疗的效果更好,能更显著地改善其内分泌功能,且较少引起不良发应。

objective ：To provide reference for the treatment of perimenopausal dysfunctional uterine bleeding, to study and analyze the curative effect of different doses of mifepristone and influence of endocrine function.Method ：A period of time in our hospital treated 104 cases of perimenopausal dysfunctional uterine bleeding patients, according to the treatment of 12.5 mg and 25 mg in two different doses of mifepristone were divided into experimental group and control group, the 12.5 mg, as the experimental group, 25 mg as observation group, continuous treatment for 3 months and 3 months of follow-up.Result ：The effective rate of the treatment group and the incidence of adverse reaction data are significantly better than the control group, the difference was statistically significant（P〈0.05）; experimental group of estradiol（E2） and progesterone（P） two hormone levels decreased significantly than that in control group, the difference was statistically significant（P〈0.05）.Conclusion ：A small dose of mifepristone in the treatment of perimenopausal dysfunctional uterine bleeding effect is better, can significantly improve the endocrine function, and bad hair should be less in the future, can be applied in clinical treatment.