复方醋酸环丙孕酮联合二甲双胍治疗多囊卵巢综合征的效果分析

Analysis of the effect of Compound Cyproterone Acetate combined with metformin on the endocrine of polycystic ovary syndrome

目的:探讨使用复方醋酸环丙孕酮联合二甲双胍治疗多囊卵巢综合征的效果。方法:选取2017年1月至2017年11月期间四川省人民医院收治的56例多囊卵巢综合征患者作为研究对象。随机将这些患者分为对照组(n=28)和观察组(n=28)。为对照组患者使用复方醋酸环丙孕酮进行治疗,为观察组患者使用复方醋酸环丙孕酮联合二甲双胍进行治疗。然后比较两组患者血清甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、总胆固醇(TC)、空腹血糖(FPG)、空腹胰岛素(FINS)、卵泡刺激素(FSH)、血清黄体生成素(LH)、睾酮(T)、雌二醇(E2)、性激素结合球蛋白(SHBG)的水平。结果:治疗后,观察组患者TG、LDL-C、LH/FSL、T及E2的水平均低于对照组患者(P<0.05),其HDL-C及SHBG的水平均高于对照组患者(P<0.05)。结论:使用复方醋酸环丙孕酮联合二甲双胍治疗多囊卵巢综合征可调节患者生殖激素及血脂的水平,改善其胰岛素抵抗的情况。

Objective ：To investigate the effect of compound cyclopropanone acetate combined with metformin on the endocrine of polycystic ovary syndrome（PCOS）.Method ：56 cases of PCOS patients in the hospital were randomly divided into two groups,control group and experimental group, the control group was given the compound cyclopropanone acetate, and the observation group was given metformin and compound cyclopropanone acetate. Then compare levels of TG,HDL-C,LDLC,TC,FPG,FINS,FSH,LH,T,E2,SHBG of 2 groups.Result ：After treatment, levels of TG,LDL-C,LH/FSL,T and E2 of experimental group are lower than that in control group（P〈0.05）, levels of HDL-C and SHBG of experimental group than that in control group（P〈0.05）.Conclusion ：The effect of compound cyclopropanone acetate combined with metformin on the endocrine of polycystic ovary syndrome are regulating levels of reproductive hormone and blood lipid, and improving insulin resistant.