雾化吸入重组人干扰素α 1b治疗小儿毛细支气管炎的效果和安全性

Safety and efficacy of aerosol inhalation of recombinant human interferon alpha 1B for the treatment of bronchiolitis in children

目的 :探讨通过让小儿雾化吸入重组人干扰素α 1b治疗其毛细支气管炎的效果和安全性。方法:选取2016年1月至10月期间郫都区人民医院儿科收治的80例毛细支气管炎患儿作为研究对象。随机将这些患儿平均分为对照组和观察组。为对照组患儿雾化吸入布地萘德进行治疗,为观察组患儿雾化吸入布地奈德和重组人干扰素α 1b进行治疗。然后观察两组患儿的生命体征、谷丙转氨酶(ALT)的水平、谷草转氨酶(AST)的水平、总胆红素(TB)的水平、总蛋白(TP)的水平、潮气量、呼气达峰时间比(t PTEF/t E)、呼气达峰容积比(VPTEF/VE)、临床症状评分、症状消失的时间、住院的时间、治疗的效果及不良反应的发生情况。结果 :治疗后,观察组患儿的呼吸频率、ALT的水平、AST的水平及各项临床症状评分均低于对照组患儿(P<0.01),其TB的水平、TP的水平、潮气量、t PTEF/t E、VPTEF/VE及治疗的总有效率均高于对照组患儿(P<0.01),其各项临床症状消失的时间及住院的时间均短于对照组患儿(P<0.01)。两组患儿不良反应的发生率相比,差异无统计学意义(P>0.05)。结论 :通过让小儿雾化吸入重组人干扰素α 1b治疗其毛细支气管炎的效果显著,可快速改善患儿的临床症状,安全性较高。

Objective：To explore the safety and efficacy of aerosol inhalation of recombinant human interferon alpha（1 b） for the treatment of bronchiolitis in children.Methods：80 cases of bronchiolitis were collected from January 2016 to October 2016 treated in Pi Du District People＇s Hospital, divided the patients into two groups, experimental group and control group, the control group were treated by budesonide inhalation therapy, the experimental group were treated by recombinant human interferon alpha 1 b combined with budesonide inhalation therapy, compared vital signs,ALT level,AST level,TB level,TP level,tidal volume,t PTEF/t E,VPTEF/VE, symptom score, symptoms disappeared time, hospitalization time, total efficiency rate and adverse reaction rate of two groups. Result ：After treatment,the frequency of wheezing, ALT level and AST level of experimental group are lower than that in control group（P〈 0.01）,TB level,TP level,tidal volume,t PTEF/t E,VPTEF/VE and total efficiency rate of experimental group are higher than that in control group（P〈 0.01）, symptoms disappeared time and hospitalization time are shorter than that in control group（P 〉0.01）,the difference of adverse reaction rate of two groups have no statistical significant（P 〈0.05）. Conclusion： The effect of Aerosol inhalation of recombinant human interferon alpha（1 b） for the treatment of bronchiolitis in children is significant,the clinical symptoms of the child patients will improved quickly treated by this therapy, the therapy with high safety.