血清脂蛋白相关磷脂酶A2和sCD40L与冠心病冠脉病变程度的关系

Relationship of serum lipoprotein related phospholipase A2 and sCD40L with degree of coronary lesions in patients with coronary heart disease

目的探讨血清中血清脂蛋白相关磷脂酶A2(PLA2)和s CD40L与冠心病患者冠脉病变程度的关系。方法选择2016年3月-2017年3月行冠状动脉造影确诊为冠心病的患者80例为研究对象,收集患者外周血,采用酶联免疫吸附法检测患者血清中PLA2和s CD40L水平,探讨其与患者冠脉斑块性质、冠心病冠脉病变程度的关系。结果根据PLA2和s CD40L中位数水平分为高水平组和低水平组,结果发现PLA2、s CD40L高水平组软斑块少于低水平组,而钙化斑块高于低水平组。Spearman相关性分析探讨PLA2和s CD40L与冠心病患者临床特点的关系,结果显示PLA2和s CD40L与患者性别、年龄、体质量指数无明显相关性,与患者斑块类型、病变支数、狭窄程度均呈正相关(P<0.05)。结论冠心病患者血清中PLA2和s CD40L是冠心病患者发生心血管事件的独立风险因素,对冠心病患者定期检查患者血清中s CD40L和PLA2水平具有重要的临床意义。

Objective To investigate the relationship of serum lipoprotein related phospholipase A2（ PLA2） and s CD40 L with the severity of coronary artery disease in patients with coronary heart disease. Methods From March 2016 to March 2017,80 patients with coronary heart disease diagnosed by coronary angiography were selected as the research objects. The peripheral blood of patients was collected. The levels of PLA2 and s CD40 L in serum were detected by enzyme-linked immunosorbent assay,and its relationship with the nature of coronary plaque and the degree of coronary artery lesion in patients with coronary heart disease. Results According to the median PLA2 and s CD40 L levels,they were divided into high level group and low level group. The results showed that soft plaque of PLA2,s CD40 L high level group were less than the low level group,and calcified plaque were higher than the low level group. Spearman correlation analysis was used to explore the relationship of PLA2 and s CD40 L with clinical characteristics of patients with coronary heart disease,and the results showed that PLA2 and s CD40 L had no significant correlation with gender,age,body mass index,which had positive correlation with the type of plaque,lesion count,degree of stenosis（ P 〈0. 05）. Conclusion PLA2 and s CD40 L in serum of patients with coronary heart disease are independent risk factors for cardiovascular events in patients with coronary heart disease. It is of clinical significance to detect serum levels of s CD40 L and PLA2 in patients with coronary heart disease.