扶肾利湿方联合连续肾脏替代(CRRT)治疗横纹肌溶解致急性肾衰竭(正虚邪实癃闭)随机平行对照研究

The Randomized Parallel Control Studies of Helped Kidney Lishi Party Joint Continuous Renal Replacement Treatment(CRRT) Rhabdomyolysis with Acute Renal Failure(Virtual and Actual Uroschesis)

[目的]观察扶肾利湿方联合连续肾脏替代(CRRT)治疗横纹肌溶解致急性肾衰竭(正虚邪实癃闭)疗效。[方法]使用随机平行对照方法,将36例住院患者简单随机分为两组。对照组18例连续肾脏替代(CRRT)。治疗组18例扶肾利湿方:黄芪30g,熟地黄20g,党参10g,土茯苓20g,车前子15g,丹参20g,苍术10g,生白术、炒薏苡仁、牛膝各15g,川芎12g,水煎200mL,1剂/d,早晚温服;连续肾脏替代治疗同对照组。连续治疗1个月为1疗程。观测临床症状、肌酸激酶(CK)、乳酸脱氢酶(LDH)、血肌红蛋白(Mb)、BUN、Scr、β2微球蛋白、不良反应。治疗1疗程(1个月),判定疗效。[结果]治疗组显效10例,有效5例,无效3例,总有效率83.33%;对照组显效8例,有效5例,无效5例,总有效率72.22%;治疗组疗效优于对照组(P<0.05)。BUN、Scr、β2微球蛋白两组均有改善(P<0.01,P<0.05),治疗组改善优于对照组(P<0.01)。CK、LDH、Mb两组均有改善(P<0.01,P<0.05),治疗组改善优于对照组(P<0.01)。[结论]扶肾利湿方联合连续肾脏替代(CRRT)治疗横纹肌溶解致急性肾衰竭(正虚邪实癃闭),疗效满意,无严重不良反应,值得推广。

[Objectives] To observe thecurative effection of help renal Lishi party joint continuous renal replacement treatment rhabdomyolysis with acute renal failure（is virtual and actual uroschesis）.[Methods]Rrandomized parallel control method was used to randomly divide 36 hospitalized patients into two groups.Control group of 18 patients with continuous renal replacement were treated. The treatment group had18 cases of kidney dehumidification.water frying 200 mL, 1 agent/d, morning and evening warm clothing;continuous renal replacement was treated with the control group. Continuous treatment 1 month is 1 treatment.Clinical symptoms, creatine kinase（CK）, lactate dehydrogenase（LDH）, blood myoglobin（Mb）, BUN, Scr,ss2 microglobulin and adverse reactions were observed. treatment 1 course（1 month）, determine curative effect. [Results] The treatment group showed 10 cases, effective 5 cases, ineffective 3 cases, and total effective rate of 83.33%. The control group showed 8 cases, 5 cases were effective, 5 cases were invalid, and the total effective rate was 72.22%. The treatment group was better than the control group（P〈0.05）. The two groups of BUN, Scr and beta 2 were improved（P〈0.01, P〈0.05）, and the treatment group improved better than the control group（P〈0.01）. The two groups of CK, LDH and Mb were improved（P〈0.01, P〈0.05）, and the treatment group improved better than the control group（P〈0.01）. [Conclusions] The help kidney lishi party joint continuous renal replacement treatment rhabdomyolysis with acute renal failure（evil is virtual to real difficulty in urination）, curative effect is satisfied, no serious adverse reactions, worthy of promotion.