摘要
[目的]观察舒血宁联合基础疗法治疗缺血性脑卒中认知功能障碍(气虚血瘀)疗效。[方法]使用随机平行对照方法,将120例门诊患者按住院号抽签法随机分为两组。对照组60例多奈哌齐+功能训练(定向力、计算力、记忆力、语言、解决问题能力)。治疗组60例舒血宁10mL+5%葡萄糖250mL,1次/d,静滴;多奈哌齐+功能训练同对照组。连续治疗2个月为1疗程。观测临床症状、定向力、计算力、记忆力、语言、解决问题能力、事件相关电位、MoCA评分、不良反应。治疗1疗程(2个月),判定疗效。[结果]N2潜伏期、P3潜伏期两组均降低(P<0.01),治疗组降低多于对照组(P<0.01);N2波幅、P3波幅两组均增加(P<0.01),治疗组增加多于对照组(P<0.01);MoCA评分两组均有增加(P<0.01),治疗组增加多于对照组(P<0.01)。[结论]舒血宁联合基础疗法治疗缺血性脑卒中认知功能障碍(气虚血瘀),疗效满意,无严重不良反应,值得推广。
[Objective] To observe the effect of Shuxuening combined therapy in the treatment of ischemic stroke(Qixu Xueyu) the curative effect of cognitive dysfunction. [Methods] Using random parallel control method, 120 outpatients were randomly divided into two groups according to hospitalization number drawing method. The control group consisted of 60 cases of donepezil+functional training(orientation, computational power, memory, language, problem-solving ability). The treatment group of 60 cases of Shuxuening 10 mL+5% glucose 250 mL, 1 time/d, intravenous drip; donepezil+function training with the control group. Continuous treatment for 2 months for 1 courses. Observation of clinical symptoms, directional force, computational power,memory, language, problem-solving ability, event-related potential, MoCA score, adverse reactions. After 1 courses of treatment(2 months), the curative effect was determined. [Result] N2 latency and the latency of P3 in two groups were decreased(P〈0.01), the treatment group decreased more than the control group(P〈0.01);N2 amplitude, P3 amplitude of two groups were increased(P〈0.01), the treatment group than the control group(P〈0.01); the MoCA scores of the two groups were increased(P〈0.01), the treatment group than the control group(P〈0.01). The treatment of ischemic stroke cognitive dysfunction. [Conclusion] Shuxuening combined with basic therapy(Qixu Xueyu), satisfactory curative effect, no serious adverse reactions, worthy of promotion.
出处
《实用中医内科杂志》
2017年第12期46-49,共4页
Journal of Practical Traditional Chinese Internal Medicine
基金
开封市科技发展项目(No.163095)~~
关键词
缺血性脑卒中
认知功能障碍
中风
舒血宁
功能训练
定向力
计算力
记忆力
语言
解决问题能力
多奈哌齐
事件相关电位
MoCA评分
中西医结合治疗
随机平行对照研究
ischemic stroke
cognitive dysfunction
stroke
Shuxuening
function training
orientation
calculation
memory
language
problem-solving
donepezil
function training
event related potentials
MoCA score
integrated traditional Chinese and western medicine therapy
randomized controlled study