孕期摄入维生素D对婴幼儿哮喘发生率影响的系统回顾和荟萃分析

Meta-analysis on association of vitamin D intake in pregnancy with infants asthma

目的进行孕期摄入维生素D对婴幼儿哮喘发生率影响的系统分析。方法检索中国知网、万方数据库、维普科技期刊数据库、PubMed数据库、OVID数据库,收集国内外关于孕期摄入维生素D对婴幼儿哮喘发生率影响的研究进行Meta分析。结果 5篇前瞻性队列研究文献和4篇RCT文献纳入研究。1)对5项前瞻性队列研究进行描述性分析显示,孕期饮食维生素D摄入量高的孕妇比摄入量低的孕妇其后代发生哮喘及喘息的几率较小,差异均具有统计学意义。2)对4项RCT中的2项进行Meta分析,共1 355组孕妇-婴幼儿纳入研究,其中补充维生素D组683例,安慰剂对照组672组,结果显示补充维生素D组的孕妇比安慰剂组的孕妇后代发生婴幼儿哮喘的风险较小(OR=0.71,95%CI:0.54~0.92,P=0.01)。结论孕期摄入较大剂量的维生素D有助于减少婴幼儿哮喘的发生率。

Objective To evaluate the association of vitamin D intake in pregnancy with infants asthma. Method VIP,Wanfang,CNKI,PubMed, and OVID databases were searched,in order to collect studies regarding association of vita- min D intake in pregnancy with infants asthma to conduct Meta-analysis. Results Totally 5 prospective cohort studies and 4 RCTs were included in this study. 1）All 5 articles had reported that higher maternal intake of vitamin D during pregnancy may significantly decrease the risk of asthma or wheeze in early childhood. 2）Two of the fore RCTs were conducted Meta-a- nalysis finally. A total of 1 355 mother-children pairs were enrolled,including 683 pairs in group with vitamin D supplemen tation and 672 pairs in group with placebo, The results showed that prenatal vitamin D supplementation was reduced the risk of infants asthma compared to the placebo （OR=0.71 ;95%CI：0.54-0.92 ;P=0.01）. Conclusion Higher prenatal in- take of vitamin D may decrease the risk of infants asthma.