出生体重对儿童青少年期血压影响的Meta分析

Correlation between birth weight and blood pressure of child and adolescent:A Meta-analysis

目的系统评价出生体重与儿童青少年期血压之间的关联,为儿童青少年高血压病因研究及防治策略制定提供理论依据。方法计算机系统检索知网、万方、维普、PubMed和Web of Science数据库,收集国内外关于出生体重与儿童青少年期血压之间关联的相关一次研究,利用SPSS13.0进行数据转化,STATA 12.0进行Meta分析。结果最终共纳入34个研究。Meta分析结果显示,与出生体重>2 500 g的儿童青少年相比,低出生体重儿患高血压的风险较高,差异有统计学意义(OR=1.20;95%CI:1.09～1.33;P<0.01),收缩压与舒张压均偏高;与出生体重<4 000 g的儿童青少年相比,高出生体重儿患高血压的风险差异无统计学意义(OR=1.03;95%CI:0.89～1.18;P>0.05),但是收缩压与舒张压均偏高。结论低出生体重与高出生体重都可能导致儿童青少年期血压升高,是儿童青少年高血压的危险因素;低出生体重对儿童青少年期的血压影响更大;可以通过母孕期的早期监测与干预来预防不正常出生体重及儿童青少年高血压。

ObjectiveTo systematically review the correlation between birth weight and blood pressure of child and adolescent, and provide a theoretical basis for the etiologic research and the prevention for hypertension of child and adolescent. MethodsComprehensive electronic searches of Chinese Web of Knowledge （CNKI）, Wang Fang, Wei Pu （VIP）, PubMed and Web of Science were conducted to identify any study reporting the correlation of birth weight and blood pressure of child and adolescent. SPSS 13.0 software was used to convert the data. Meta-analysis was conducted with STATA 12.0 software. ResultsThirty four researches were included in this study. The results of meta-analysis showed that low birth weight children or adolescents had a higher risk of hypertension with a significant difference compared to the group which birth weight greater than 2 500 g （OR=1.20; 95% CI： 1.09-1.33; P〈0.01）. Its systolic blood pressure and diastolic blood pressure was on the high side. In addition, it showed that no significant differences were found between hypertension and high birth weight （OR=1.03; 95% CI： 0.89-1.18; P〉0.05）. But its systolic blood pressure and diastolic blood pressure was on the high side too. ConclusionsAbnormal birth weight is probably a risk factor of child and adolescent high blood pressure. Low birth weight has greater influence on blood pressure of children and adolescents. It can be detected early to prevent abnormal birth weight and child hypertension.