健康管理中代谢综合征与良性前列腺增生之间的关系

Exploration of the relationship between metabolic syndrome and benign prostatic hyperplasia in health management

目的探讨健康管理中代谢综合征与良性前列腺增生之间的关系。方法选择2015年1月至2015年12月在本院健康管理中心进行健康检查的5 721例良性前列腺增生患者。测量身高、体重,计算体重指数(BMI),测量动脉压,检测血清前列腺特异抗原(PSA)、胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖、餐后血糖、尿酸(UA);行前列腺B超检查,测量前列腺体积。根据是否合并代谢综合征分为两组,合并代谢综合征组为观察组,不合并代谢综合征组为对照组,分析两组间代谢综合征各指标及前列腺体积的差别;分析代谢综合征各项指标与良性前列腺增生及前列腺体积的相关性。对合并代谢综合征组患者进行健康干预1年,观察前列腺体积及症状的变化。结果合并代谢综合征组患者中,BMI、TG、TC、血糖(空腹+餐后2 h)及前列腺体积、血清PSA均高于对照组;高血压、高甘油三酯血症与良性前列腺增生诊断相关;前列腺体积与肥胖、高血压、高密度脂蛋白降低和代谢综合征相关。进行健康干预后,代谢综合征的指标降低,患者良性前列腺增生的症状较前缓解。结论肥胖、高血压、高密度脂蛋白降低和代谢综合征相关;代谢综合征和良性前列腺增生存在一定的关系,对代谢综合征进行健康干预将有助于对良性前列腺增生的健康管理,从而延缓良性前列腺增生疾病的发生和发展。

ObjectiveTo explore the relationship between metabolic syndrome and benign prostatic hyperplasia in health management. MethodsA total of 5 721 patients of prostate hyperplasia was collected and divided into two groups according to metabolic syndrome. The height, weight, body mass index （BMI）, and arterial blood pressure were measured. The serum PSA, cholesterol （TC）, triglyceride （TG）, high-density lipoprotein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL-C）, fasting blood glucose （FBG）, postprandial blood glucose, uric acid （UA） prostate specific antigen （PSA）, and free prostate specific antigen （fPSA） were monitored. The volume of prostate was measured with ultrasound. The difference was analyzed between two groups of metabolic syndrome components and the volume of prostate. The correlation between various indicators of metabolic syndrome and prostate hyperplasia and prostate volume were analyzed. Health intervention was made to observe the changes of prostate volume and symptoms in the patients with metabolic syndrome for one year. ResultsBMI, TG, TC, BG, prostate volume, and serum PSA were higher in the patients with metabolic syndrome than in the control group. There was significant correlation between hyperlipidemia, benign prostatic hyperplasia and diagnosis of hypertension. Prostate volume was positively correlated with obesity, hypertension, high-density lipoprotein and metabolic syndrome. After health intervention, the indicators of metabolic syndrome decreased, and the symptoms of benign prostatic hyperplasia were relieved. ConclusionsReduced obesity, hypertension, low high-density lipoprotein and the metabolic syndrome and prostate volume were positively related. Metabolic syndrome and prostatic hyperplasia exists certain relationship. The metabolic syndrome health interventions will be necessary to manage the health of prostate hyperplasia, thus delays the occurrence and development of prostate hyperplasia disease.