运动锻炼对鼻咽癌患者生活质量的影响

Effect of exercise training on quality of life of patients with nasopharyngeal carcinoma

目的探讨运动锻炼对鼻咽癌患者生活质量的影响。方法选取82例鼻咽癌患者依据入院顺序随机分为对照组和研究组,各41例,对照组实施常规头颈部功能锻炼,研究组另实施全身运动锻炼,比较治疗前后2组癌症疲乏量表(CFS)、视觉模拟疼痛(VAS)评分、焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分、不良事件发生率及生活质量测量量表(QLQ-C30)评分。结果治疗前,2组CFS、VAS、SAS、SDS、QLQ-C30评分比较,差异无统计学意义(P>0.05);与治疗前比较,治疗后2组CFS、VAS、SAS、SDS、QLQ-C30评分均降低(P<0.05),且研究组较对照组降低更显著(P<0.05);研究组张口困难、口腔黏膜炎发生为率14.63%、19.51%,低于对照组的34.15%、41.46%(P<0.05)。结论运动锻炼应用在放化疗鼻咽癌患者中,可有效减轻患者癌疲乏,缓解焦虑抑郁情绪,达到改善临床症状及提高生活质量的目的。

Objective To investigate the effect of exercise training on the quality of life of patients with nasopharyngeal carcinoma. Methods A total of 82 patients with nasopharyngeal carci- noma treated in our hospital were randomly divided into control group and study group according to admission order, with 41 cases in each group. The control group was given routine head and neck function exercise, and the study group was additionally given body exercise. Scores of the Cancer Fa- tigue Scale （CFS）, Visual Analogue Scale （VAS）, Self-rating Anxiety Scale （SAS）, Self-rating De- pression Scale （ SDS）, the incidence of adverse events and quality of life scale （QLQ-C30） scores in the two groups were observed. Results There were no significant differences in scores of CFS, VAS, SAS, SDS and QLQ-C30 between the two groups before treatment （P 〉 0.05）. After treatment, the above-mentioned scores decreased significantly, and the study group decreased more than the control group （ P 〈 0.05 ）. The incidence of open mouth difficulty and oral mucositis in the study group were 14.63% and 19.51%, respectively, and were significantly lower than 34.15% and 41.46% in the control group （P 〈 0.05 ）. Conclusion Exercise training can obviously relieve anxiety, depression and cancer fatigue, and improve the clinical symptoms and quality of life of patients with nasopharyn- geal carcinoma.