美托洛尔联合卡托普利治疗慢性心力衰竭的效果观察

Clinical Observation of Metoprolol Combined with Captopril in Treatment of Chronic Heart Failure

目的:观察美托洛尔联合卡托普利治疗慢性心力衰竭的效果。方法:将60例慢性心力衰竭患者随机分为观察组和对照组,每组30例,两组均予强心、利尿、扩血管、抗感染对症治疗。其中,对照组给予卡托普利,观察组加用美托洛尔,疗程均为1个月。比较两组患者的临床疗效及治疗前后各项心功能指标的变化情况。结果:观察组患者治疗后的总有效率93.33%,显著高于对照组的73.33%,差异有统计学意义(字2=6.973,P<0.05)。治疗后,观察组患者LVEF(51.51±8.23)%,LVESD(32.26±6.45)mm,LVEDD(42.82±6.35)mm,显著优于对照组,差异均有统计学意义(t=5.732、2.765、3.876,P<0.05)。结论:美托洛尔、卡托普利二者联用治疗慢性心力衰竭可以显著提高临床效果,改善心功能,提高生存质量。

Objective：To observe the efficacy of Metoprolol combined with Captopril in treatment of chronic heart failure.Method：A total of 60 patients with chronic heart failure were randomly divided into the observation group and the control group,30 cases in each group.The two groups were treated with cardiotonic,diuretic,vasodilator,anti infection and symptomatic treatment,and the control group received Captopril,the observation group was treated with Metoprolol.The course of treatment was 1 month.The clinical efficacy and the changes of cardiac function indexes before and after treatment were compared.Result：The total efficiency of the observation group was 93.33%,which was significantly higher than 73.33% of the control group,the difference was statistically significant（ 字2=6.973,P0.05）.The LVEF,LVESD,LVEDD were（51.51±8.23）%,（32.26±6.45）mm,（42.82±6.35）mm in the observation group after treatment respectively,which were significantly better than those in the control group,the differences were statistically significant（t=5.732,2.765,3.876,P0.05）.Conclusion：Metoprolol and Captopril in the treatment of chronic heart failure can significantly improve the clinical efficacy,improve cardiac function,and improve the quality of life in patients.