恶性肿瘤中miR-143与其靶基因Bcl-2研究进展

Research progress of miR-143 and it's target gene Bcl-2 in malignant tumors

miRNA是20~24个核苷酸长度的、非编码的单链小分子RNA,可通过抑制转录、翻译调控其他基因的表达。已有大量研究证明,miR-143在肿瘤的发展进程中发挥着重要作用。在许多恶性肿瘤中,miR-143的表达水平较癌旁正常组织均有不同程度的下调。相反,Bcl-2蛋白在恶性肿瘤中的表达水平明显高于组织。并且已有研究表明,Bcl-2是miR-143的作用靶位点之一。miR-143通过作用于Bcl-2的3'UTR,形成凋亡复合体,激活caspase-3,后逐渐引起一系列caspase级联反应,从而调控肿瘤细胞的凋亡。

Mi RNAs are small non-coding RNA molecules of 20~24 nt that regulate the expression of other genes by transcriptional inhibition or translational repression. Multiple lines of evidence suggest that miRNAs play important roles in tumor development and progression. Compared with adjacent normal tissues, the expression level of miR-143 was lower than these tissues in many malignant tumors. On the contrary, the expression level of Bcl-2 protein was significantly higher in malignant tumors than adjacent tissues, and it has been shown that Bcl-2 is one of the target sites of miR-143. Formed a complex of apoptosis activates 3 by miR-143 target 3＇ untranslated region of Bcl-2 and then induces a series of caspase cascade reaction, which can regulate the apoptosis of tumor cells.