摘要
机体内脂质的稳态受到多条信号通路及其交错形成的复杂网络的调节,其中过氧化物酶体增殖物激活受体(peroxisome proliferator-activated receptor,PPAR)信号通路可促进脂质生成,而腺苷酸活化的蛋白激酶(AMP-activated protein kinase,AMPK)信号通路促进脂肪酸的分解。miRNA作为一种转录后调控因子,可以调控脂质合成、分解等过程,在脂质代谢异常相关的疾病中具有重要的调控地位。本文基于61个已被报道受miRNA调控的脂质代谢相关基因,绘制这些基因之间的互作网络,从PPAR以及AMPK/SREBPs(sterol regulatory element-binding proteins)信号途径的角度综述了miRNA对脂质代谢的调控作用。
The lipid homeostasis in organism is regulated by a complex network formed by multiple signal pathways. Normally, peroxisome proliferator-activated receptor（PPAR） signaling pathway promotes lipogenesis, AMP-activated protein kinase（AMPK） signaling pathway enhances lipolysis oppositely. As a post-transcriptional regulator, miRNAs participated in fat synthesis or fatty acid oxidation and play an important role in the development of diseases related to abnormal lipid metabolism. In this review, a co-regulated network is constructed with those genes targeted by miRNAs, which have been validated by previous reported, elaborating the functional role of miRNAs in lipid metabolism from the point of PPAR and AMPK/SREBPs（sterol regulatory element-binding proteins） signaling pathways.
出处
《生命的化学》
CAS
CSCD
2017年第6期1017-1029,共13页
Chemistry of Life
基金
国家"转基因生物新品种培育"科技重大专项(2014ZX08009-051B)
