抗增殖蛋白与线粒体自噬的研究进展

Research advances on prohibitins and mitophagy

抗增殖蛋白(prohibitins,PHB)普遍存在于生物细胞中,其主要定位于线粒体内膜,参与线粒体自噬的发生发展,并在线粒体自噬的过程中起着关键角色和发挥着重要作用。本文着重讨论抗增殖蛋白与线粒体自噬的关系,及其对相关疾病的作用和影响。

Prohibitins（PHB） are commonly found in biological cells, which are mainly located in inner mitochondrial membrane and participate in the occurrence and development of mitophagy. So it can play a key role in the process of mitophagy. This article focuses on the relationship between prohibitins and mitophagy, and its functions and effects on related diseases.